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Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous
(BIOMED Central Ltd., 2017)
Background: The cytochromes P450 (P450s) are a large superfamily of heme-containing monooxygenases involved in the oxidative metabolism of an enormous diversity of substrates. These enzymes require electrons for their ...
Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions
(2009)
Copper toxicity has been associated to the capacity of free copper ions to catalyze the production of superoxide anion and hydroxyl radical, reactive species that modify the structure and/or function of biomolecules. In ...
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
(2010)
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Modulation of cytochrome P450 activity in the kidney of rats following long-term red wine exposure
(2002)
Cytochrome P450 (CYP)-dependent oxidation of lauric acid, p-nitrophenol and ethanol by microsomal fractions of kidney were studied in control rats and in animals given either ethanol, red wine, or alcohol-free red wine for ...
Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization
(National Academy of Sciences, 2016)
Anthraquinones are a large family of secondary metabolites (SMs) that are extensively studied for their diverse biological activities. These activities are determined by functional group decorations and the formation of ...
Cytochrome P450-mediated drug interactions in COVID-19 patients: Current findings and possible mechanisms
At the end of 2019, the entire world has witnessed the birth of a new member of coronavirus family in Wuhan,
China. Ever since, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has swiftly invaded
every ...
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y perspectivas terapéuticas
(2008)
Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy ...
cDNA isolation and expression of nicotinamide adenine dinucleotide phosphate-dependent cytochrome P450 reductase gene in the chagas disease vector triatoma infestans
(American Society of Tropical Medicine and Hygiene, 2018-03)
Pyrethroid resistance has been detected in Triatoma infestans (Hemiptera: Reduviidae), which was atributed to target site insensitivity and increased oxidative metabolism of the insecticide by cytochrome P450s. Nicotinamide ...
Actividad del citocromo P450 y su alteración en diversas patologías
(SOC MEDICA SANTIAGO, 2004-01)
Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate ...