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Classical and fragment-based hologram structure-activity relationships for a series of analgesic cyclic imides
(BENTHAM SCIENCE PUBL LTD, 2008)
Cyclic imides have been widely employed in drug design research due to their multiple pharmacological and biological properties. In the present study, two-dimensional quantitative structure-activity relationship (2D QSAR) ...
Anticonvulsant activity of ringed enaminones: a QSAR study
(Wiley VCH Verlag, 2009-12)
The formalism of the QSAR Theory is employed to establish mathematical relationships that link the molecular structure of ringed enaminones to their observed antiepileptic activity. The design of predictive linear regression ...
Fragment-based and classical quantitative structure–activity relationships for a series of hydrazides as antituberculosis agents
(2008)
Worldwide, tuberculosis (TB) is the leading cause of death among curable infectious diseases. Multidrug-resistant
Mycobacterium tuberculosis is an emerging problem of great importance to public health, and there is an ...
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease
(De Gruyter, 2019-02-14)
Parkinson's disease is one of the most common neurodegenerative illnesses in older persons and the leucine-rich repeat kinase 2 (LRRK2) is an auspicious target for its pharmacological treatment. In this work, quantitative ...
2D Chemical Drawings Correlate to Bioactivities: MIA-QSAR Modelling of Antimalarial Activities of 2,5-Diaminobenzophenone Derivatives
(Soc Brasileira QuimicaSao PauloBrasil, 2011)
Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi
(INFORMA HEALTHCARE, 2008)
Chagas` disease is a parasitic infection widely distributed throughout Latin America, with devastating consequences in terms of human morbidity and mortality. Cruzain, the major cysteine protease from Trypanosoma cruzi, ...
2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitors
(2007)
Coronary heart disease (CHD) is one of the major causes of human death. The most successful therapeutic approach available is based on the reduction of low density-lipoprotein cholesterol (LDL-C). However, it is believed ...
Modelos de QSAR aplicados ao estudo de inibidores imidazopiridínicos da tirosina quinase do baçoQSAR models applied to the study of imidazopyridine inhibitors sleen tyrosine kinase
(UNIVERSIDADE FEDERAL DE LAVRASDQI - Programa de Pós-graduaçãoUFLABRASIL, 2015)