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Mostrando ítems 11-20 de 199
Ca(2+) binding to c-state of adenine nucleotide translocase (ANT)-surrounding cardiolipins enhances (ANT)-Cys(56) relative mobility: A computational-based mitochondrial permeability transition study
(ELSEVIER SCIENCE BV, 2009)
The oxidation of critical cysteines/related thiols of adenine nucleotide translocase (ANT) is believed to be an important event of the Ca(2+)-induced mitochondrial permeability transition (MPT), a process mediated by a ...
Mechanisms of Action of Eicosapentaenoic Acid in Bladder Cancer Cells In Vitro: Alterations in Mitochondrial Metabolism, Reactive Oxygen Species Generation and Apoptosis Induction
(ELSEVIER SCIENCE INC, 2009)
Purpose: Eicosapentaenoic acid has been tested in bladder cancer as a synergistic cytotoxic agent in the form of meglumine-eicosapentaenoic acid, although its mechanism of action is poorly understood in this cancer. The ...
Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus
(BioScientifica, 2017-04)
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria. The functional ...
Oxygen metabolism in human placenta mitochondria
(Springer, 2014-09)
Due to the high metabolic demands of the placental tissue during gestation, we decide to analyzed the mitochondrial bioenergetic functions in the human term placenta. Different mitochondrial morphological parameters, ...
HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition
(2017-12-14)
Human dihydroorotate dehydrogenase (HsDHODH) enzyme has been studied as selective target for inhibitors to block the enzyme activity, intending to prevent proliferative diseases. The N-terminal microdomain seems to play ...
Insight into the Properties of Cardiolipin Containing Bilayers from Molecular Dynamics Simulations, Using a Hybrid All-Atom/United-Atom Force Field
(AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2012)
Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci
(American Society for MicrobiologyAntimicrobial Agents and Chemotherapy, 2013)
Mitochondrial susceptibility in a model of paraquat neurotoxicity
(Taylor & Francis, 2013-08)
Paraquat is a highly toxic herbicide capable of generating oxidative stress and producing brain damage after chronic exposure. The aim of this research was to investigate the contribution of mitochondria to the molecular ...