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Mimicking the tumor microenvironment: Fibroblasts reduce miR-29b expression and increase the motility of ovarian cancer cells in a co-culture model
(2019-08-13)
Ovarian cancer (OC) is a highly prevalent gynecological malignancy worldwide. Throughout ovarian carcinogenesis, the crosstalk between cellular components of the microenvironment, including tumor cells and fibroblasts, is ...
A Mir-335/cox-2/pten Axis Regulates The Secretory Phenotype Of Senescent Cancer-associated Fibroblasts
(Impact Journals LlcAlbany, 2016)
Análise proteômica da sinalização heterotípica em cultura celular de melanoma
(Universidade Federal de São Paulo (UNIFESP), 2021)
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this ...
Isolation and characterization of myofibroblast cell lines from oral squamous cell carcinoma
(Spandidos Publ LtdAthensGrécia, 2011)
Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A
(Elsevier Science BvAmsterdamHolanda, 2011)
Interleukin-1 beta, transforming growth factor beta 1, prostaglandin E2, and fibronectin levels in the conditioned mediums of bone marrow fibroblast cultures from lung and breast cancer patients
(Springer Verlag Berlín, 2002)
We analyzed the ability of the bone marrow (BM) stromal cells to achieve confluence and their proliferative capacity in BM primary cultures from 30 untreated lung cancer patients (LCP), 27 breast cancer patients (BCP), and ...
Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer
(Omics International, 2016-05)
Background: The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response. In this study, we evaluated the ...
Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer
(Faculdade de Medicina / USP, 2013-06-01)
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy. Identifying myeloid-derived suppressor cells and ...
Aberrant upregulation of CDK1 contributes to medroxyprogesterone acetate (MPA) resistance in cancer-associated fibroblasts of the endometrium
(2022-11-05)
The response to medroxyprogesterone acetate (MPA) decreases as endometrial disease progresses from the benign to malignancy. In a mouse model, progesterone receptor (PR) expression in normal fibroblasts is accountable for ...