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Novel Medical Therapies for Pituitary Tumors
(Karger, 2010-07)
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical removal or at least ...
Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs
(Endocrine Society, 2006-09)
Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph ...
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum
(Wiley-liss, Div John Wiley & Sons Inc, 2016-02)
Exposure to adverse environmental conditions can elicit a stress response, which results in an increase in endogenous corticosterone levels. In early life stages, it has been thoroughly demonstrated that amphibian larval ...
Impacto do tratamento com GH sobre as funções tireoidiana e adrenal
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-07-01)
Somatotrophic status is a major determinant of both thyrotrophic and corticotrophic axis. In growth hormone deficient patients, somatotrophic replacement increases the conversion rate of the inactive form of the thyroid ...
Role for postoperative cortisol response to desmopressin in predicting the risk for recurrent Cushing`s disease
(WILEY-BLACKWELL, 2008)
In the early postoperative period of Cushing`s disease patients, desmopressin may stimulate ACTH secretion in the remnant corticotrophic tumour, but not in nontumour suppressed cells. Objective The aim of this study is to ...
Expression of neurotensin and its receptors in pituitary adenomas
(WILEY-BLACKWELL, 2008)
The neurotensin (NT) produced in the hypothalamus and in pituitary gonadotrophs and thyrotrophs participates in neuroendocrine regulation. Recently, the involvement of this peptide in normal and neoplastic cell proliferation ...
MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors
(ENDOCRINE SOC, 2009)
Context: MicroRNAs (miRNAs) are small noncoding RNAs, functioning as antisense regulators of gene expression by targeting mRNA and contributing to cancer development and progression. More than 50% of miRNA genes are located ...
Germline mutation analysis of Tpit in Poodle dogs with ACTH-dependent hyperadrenocorticism
(ARQUIVO BRASILEIRO MEDICINA VETERINARIA ZOOTECNIABELO HORIZONTE, 2012)
There is a high incidence of pituitary-dependent hyperadrenocorticism (PDH) in Poodle dogs, with family members being affected by the disease, suggesting a genetic involvement. Tpit is an obligate transcription factor for ...