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Mostrando ítems 11-20 de 20
A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function
(American Society for Biochemistry and Molecular Biology, 2011-01-28)
The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive ...
Síndrome miasténico congénito por deficiencia de rapsina: reporte de caso con nueva mutación y heterocigosidad compuesta
(Medwave Estudios Limitada, 2019)
Introduction: The congenital myasthenic syndromes are a heterogeneous group of genetic disorders characterized by an abnormal synaptic transmission in the neuromuscular plate. Report: We present a two-year-old patient, ...
Funções motoras em camundongos deficientes do transportador vesicular de acetilcolina (VAChT)
(Universidade Federal de Minas GeraisUFMG, 2006-08-10)
Acetylcholine (ACh)mediated neurotransmission has a crucialrole in the control of movement. Release of ACh depends on its storagein synaptic vesicles, a step controlled by the activity of the VAChT. Wedeveloped a genetically ...
Increased Cholinergic Tone Causes Pre-synaptic Neuromuscular Degeneration and is Associated with Impaired Diaphragm Function
(2021-04-15)
In vertebrates, muscle activity is dependent on acetylcholine (ACh) released from neuromuscular junctions (NMJs), and changes in cholinergic neurotransmission are linked to a variety of neuromuscular diseases, including ...
Neurotransmitter GABA Activates Muscle but not a7 Nicotinic Receptors
(American Society For Pharmacology And Experimental Therapeutics, 2015-03)
Cys-loop receptors are neurotransmitter-activated ion channels involved in synaptic and extrasynaptic transmission in the brain and are also present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR) belong ...
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...
Miastenia grave juvenil e sindromes miastenicas congenitas
([s.n.], 2000)
Evento com aparente risco de morte recorrente como manifestação inicial de síndrome miastênica congênitaEvento con aparente riesgo de muerte recurrente como manifestación inicial de síndrome miasténico congénitoRecurrent apparent life-threatening event as the first manifestation of congenital myasthenia
(Sociedade de Pediatria de São Paulo, 2013)
Alterações neuromusculares em modelos animais de disfunção colinérgica e sua relação com as Síndromes Miastênicas Congênitas
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-04-26)
In mammals, muscle activity is dependent on acetylcholine (ACh) release from neuromuscular junctions (NMJs), and changes with the cholinergic neurotransmission are associated with a variety of neuromuscular disorders, ...
Enfermedades de la placa neuromuscular
(Universidad del RosarioEspecialización en NeurologíaFacultad de Medicina, 2013)
In this chapter we describe the neuromuscular transmission disorders, the epidemiology, clinical features, diagnosis and treatment