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The role of mitochondria and biotransformation in abamectin-induced cytotoxicity in isolated rat hepatocytes
(2013-03-01)
Abamectin (ABA), which belongs to the family of avermectins, is used as a parasiticide; however, ABA poisoning can impair liver function. In a previous study using isolated rat liver mitochondria, we observed that ABA ...
Interaction between the plant ApDef1 defensin and Saccharomyces cerevisiae results in yeast death through a cell cycle- and caspase-dependent process occurring via uncontrolled oxidative stress
(Elsevier Science, 2017-01)
Background Plant defensins were discovered at beginning of the 90s' however, their precise mechanism of action is still unknown. Herein, we studied ApDef1-Saccharomyces cerevisiae interaction. Methods ApDef1-S. cerevisiae ...
Apoptotic activities of cardenolide glycosides from Asclepias subulata
(2016-12-04)
Ethnopharmacological relevance Asclepias subulata Decne. (Apocynaceae) is a shrub occurring in Sonora-Arizona desert. The ethnic groups of Sonora, Mexico, Seris and Pimas, use this plant for the treatment of sore eyes, ...
Marcadores de apoptose em células da granulosa humanas e sua correlação com parametros clínicos de pacientes submetidas a hiperestimulação ovariana controlada
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE PATOLOGIAPrograma de Pós-Graduação em PatologiaUFMG, 2019-02-21)
The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa cells are essential in normal follicular maturation process since they produce steroidal hormones and growth factors, and they play ...
The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells
(Pergamon-Elsevier Science Ltd, 2011-08)
Manganese (Mn) is a trace element known to be essential for maintaining the proper function and regulation of many biochemical and cellular reactions. However, chronic exposure to high levels of Mn in occupational or ...
O papel das proteínas ligadoras de guanilato (GBP) na ativação de caspase-11 e gasdermina-D (GSDMD) no controle da infecção causada pela bactéria Brucella abortus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2019-03-29)
Brucella abortus is a Gram-negative bacterium that causes a disease in humans and cattle termed brucellosis. Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like ...