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Mostrando ítems 11-20 de 314
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate
(Elsevier Ireland, 2016-01)
Background: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species ...
Papel da CaMKII hipocampal no processamento das memórias de reconhecimento de objetos
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM PSICOBIOLOGIA, 2023)
Systemic Sympathoexcitation Was Associated with Paraventricular Hypothalamic Phosphorylation of Synaptic CaMKII alpha and MAPK/ErK
(Frontiers Media Sa, 2017-08-03)
Systemic administration of adrenergic agonist (Isoproterenol; ISOP) is known to facilitate cardiovascular changes associated with heart failure through an upregulation of cardiac toll-like receptor 4 (TLR4). Furthermore, ...
CaMKII-dependent responses to ischemia and reperfusion challenges in the heart
(Frontiers, 2014-05)
Ischemic heart disease is a leading cause of death, and there is considerable imperative to identify effective therapeutic interventions. Cardiomyocyte Ca2+ overload is a major cause of ischemia and reperfusion injury, ...
Role of CaMKII and ROS in rapid pacing-induced apoptosis
(Elsevier, 2013-10)
Tachycardia promotes cell death and cardiac remodeling, leading to congestive heart failure. However, the underlying mechanism of tachycardia- or rapid pacing (RP)-induced cell death remains unknown. Myocyte loss by apoptosis ...
The role of CaMKII regulation of phospholamban activity in heart disease
(Frontiers, 2014-01-27)
Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN ...