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QSAR studies on blood-brain barrier permeation
(Bentham Science Publishers, 2006-03)
This review focuses on both physicochemical and theoretical QSAR methods for the prediction of drug transport across the blood-brain barrier (BBB). Special emphasis is given to the recent progress that has been made in the ...
Lipid-based nanoformulations in the treatment of neurological disorders
(Taylor and Francis Ltd, 2020)
High performance collection of cerebrospinal fluid in rats: evaluation of erythropoietin penetration after osmotic opening of the blood-brain barrier
(Elsevier, 2013-09)
An important issue to be considered when studying a new drug for treatment of central nervous system (CNS) diseases is its ability to cross the blood–brain barrier (BBB) and distribute throughout the brain. As cerebrospinal ...
Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS
(Cell Press, 2010-09)
Upon entry into the central nervous system (CNS), serum insulin-like growth factor-1 (IGF-I) modulates neuronal growth, survival, and excitability. Yet mechanisms that trigger IGF-I entry across the blood-brain barrier ...
Understanding the role of the blood brain barrier and peripheral inflammation on behavior and pathology on ongoing confined cortical lesions
(Elsevier, 2021-11)
Background: Inflammation in the Central Nervous System (CNS) is associated with blood brain barrier (BBB) breakdown during the early stages of Multiple Sclerosis (MS), indicating a facilitated entry of waves of inflammatory ...
Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System
(Pergamon-Elsevier Science Ltd, 2019-05)
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by ...
A fragment-based approach for the in silico prediction of blood-brain barrier permeation
(Sociedade Brasileira de Química, 2012)
Blood-brain barrier (BBB) permeation is an essential property for drugs that act in the central nervous system (CNS) for the treatment of human diseases, such as epilepsy, depression, Alzheimer's disease, Parkinson disease, ...
Extracellular vesicles through the blood–brain barrier: a review
(2022)
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between ...
Role of microfluidics in blood-brain barrier permeability cell culture modeling: Relevance to CNS disorders
(Bentham Science Publishers, 2016)