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Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
(Wiley, 2020)
Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1
(NATL ACAD SCIENCES, 2006-12-26)
Multiple phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic pepticles ...
Wnt/beta-Catenin Signaling in Oral Carcinogenesis
(MDPI, 2020)
Oral carcinogenesis is a complex and multifactorial process that involves cumulative
genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair
and defective cell death. At the ...
Increased nuclear beta-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia
(Medicina Oral, 2015)
Background: Deregulation of beta-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to ...
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: Oncogenic Wnt/beta-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT-5A, in lip carcinogenesis. The aim of this study was to investigate ...
The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (beta-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)
(Springer, 2014-04-01)
Soybean isoflavonoids have received significant attention due to their potential anticarcinogenic and antiproliferative effects and possible role in many signal transduction pathways. However, their mechanisms of action ...
Activation Of The Wnt/beta-catenin Pathway In Pancreatic Beta Cells During The Compensatory Islet Hyperplasia In Prediabetic Mice
(Academic Press Inc Elsevier ScienceSan Diego, 2016)
Aberrant expression of E-cadherin and beta-catenin proteins in placenta of bovine embryos derived from somatic cell nuclear transfer
(CSIRO Publishing, 2012-01-01)
Abnormal placental development is common in the bovine somatic cell nuclear transfer (SCNT)-derived fetus. In the present study, we characterised the expression of E-cadherin and beta-catenin, structural proteins of adherens ...