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Mostrando ítems 11-20 de 25
Bimodal therapeutic agents against Glioblastoma, one of the most lethal forms of cancer
(Wiley VCH Verlag, 2020-08)
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced ...
Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapyOptimization of the classical oral cancerization protocol in hamster to study oral cancer therapy
(Wiley Blackwell Publishing, IncWiley Blackwell Publishing, Inc, 2020-09)
Objective(s): The hamster carcinogenesis model recapitulates oral oncogenesis. Dimethylbenz[a]anthracene (DMBA) cancerization induces early severe mucositis, affecting animal's welfare and causing tissue loss and pouch ...
Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model
(Springer Heidelberg, 2013-04)
Boron neutron capture therapy (BNCT) is based on selective accumulation of 10B carriers in tumor followed by neutron irradiation. We previously proved the therapeutic success of BNCT mediated by the boron compounds ...
Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats
(Springer, 2013-11)
Boron neutron capture therapy (BNCT) was proposed for untreatable colorectal liver metastases. Employing an experimental model of liver metastases in rats, we recently demonstrated that BNCT mediated by boronophenylalanine ...
Boron neutron capture therapy for oral precancer: proof of principle in an experimental animal model
(Wiley, 2013-02)
OBJECTIVES: Field-cancerized tissue can give rise to second primary tumours, causing therapeutic failure. Boron neutron capture therapy (BNCT) is based on biological targeting and would serve to treat undetectable foci of ...
Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer
(Springer, 2017-08)
The aim of the present study was to evaluate, for the first time, the abscopal effect of boron neutron capture therapy (BNCT). Twenty-six BDIX rats were inoculated subcutaneously with 1 × 106 DHD/K12/TRb syngeneic colon ...
Assessment of biological effectiveness of boron neutron capture therapy in primary and metastatic melanoma cell lines
(Taylor & Francis Ltd, 2014-08)
Purpose: In order to optimize the effectiveness of Boron Neutron Capture Therapy (BNCT), Relative Biological Effectiveness (RBE) and Compound Biological Effectiveness (CBE) were determined in two human melanoma cell lines, ...
Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung
(Taylor & Francis Ltd, 2019-05)
Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non-resectable, ...
Boron neutron capture therapy (BNCT) for the treatment of spontaneous nasal planum squamous cell carcinoma in felines
(Springer Verlag Berlín, 2007-10)
Recently, Boron neutron capture therapy (BNCT) was successfully applied to treat experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa, with no damage to normal tissue. It was also shown that treating ...
Experimental studies of boron neutron capture therapy (BNCT) using histone deacetylase (HDACI) sodium butyrate, as a complementary drug for the treatment of poorly differentiated thyroid cancer (PDTC)
(Pergamon-Elsevier Science Ltd, 2020-10)
Purpose: The present study analyzed different protocols of administration of boronophenylalanine (BPA) and sodium butyrate (NaB) to increase the BNCT efficacy for poorly differentiated thyroid cancer (PDTC). Materials and ...