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Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
(AMER THORACIC SOC, 2001)
Administration of bleomycin into the lungs of experimental animals has been utilized as a model to understand human pulmonary fibrosis. Most of the studies, however, have focused on early stages of the lung reaction. We ...
Therapeutic potential of bleomycin plus suicide or interferon-β gene transfer combination for spontaneous feline and canine melanoma
(Impact Journals, 2017-12)
We originated and characterized melanoma cell lines derived from tumors of two feline and two canine veterinary patients. These lines reestablished the morphology, physiology and cell heterogeneity of their respective ...
Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
(Springer, 2016-11)
Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure ...
Is the combination of mitomycin C, bleomycin and methotrexate effective as a neoadjuvant treatment for cervical cancer in women?
(I R O G CANADA, INC, 2011)
Objective: To determine the effectiveness of the combination of mitomycin C, bleomycin and methotrexate as a neoadjuvant treatment in preparation for surgical treatment of cervical cancer. Methods and Materials: Twenty-seven ...
Effect of 0.25 ppm Ozone exposure on. pulmonary damage induced by bleomycin
(SOCIEDAD BIOLGIA CHILE, 2005)
To study the effect of ozone in a chronically damaged lung. we used a bleomycin (BLM) induced pulmonary fibrosis model. Both endotracheal instillation of BLM and O-3 exposure both produce lung inflammation and fibrosis. ...
Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions
(De Gruyter, 2016-03)
Background. Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective response rate of around 80%. ...
Effect of thiol compounds on bleomycin-induced DNA and chromosome damage in human cells
(Heldref Publications, 2013-02)
Non-protein thiols are considered radioprotectors, preventing DNA damage by ionizing radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may prevent DNA damage produced by this antibiotic. ...
DNA and chromosome damage induced by bleomycin in mammalian cells: An update
(Elsevier Science, 2018-01)
Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including ...