Buscar
Mostrando ítems 11-20 de 205
BCL2l10 is overexpressed in melanoma downstream of STAT3 and promotes cisplatin and ABT-737 resistance
(Multidisciplinary Digital Publishing Institute, 2020-12)
The anti-apoptotic proteins from the Bcl-2 family are important therapeutic targets since they convey resistance to anticancer regimens. Despite the suspected functional redundancy among the six proteins of this subfamily, ...
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
(Elsevier, 2011-04)
The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...
CD4(+) T cells downregulate Bcl-2 in germinal centers
(Springer/plenum PublishersNew YorkEUA, 2005)
Methods to probe calcium regulation by BCL-2 family members
(Springer Nature, 2019)
BCL-2 family members have additional roles beyond direct regulation of mitochondrial outer membrane permeabilization (MOMP) in apoptosis. One such important function is the release of calcium from the endoplasmic reticulum ...
TMBIM protein family: ancestral regulators of cell death
(Nature Publishing Group, 2015)
The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as ...
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
(2008)
Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising ...