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Transactivation activity and nucleocytoplasmic transport of β-catenin are independently regulated by its C-terminal end
(Elsevier, 2015)
The key protein in the canonicalWnt pathway is β-catenin, which is phosphorylated both in absence and presence
ofWnt signals by different kinases. Upon activation in the cytoplasm, β-catenin can enter into the nucleus ...
Wnt/beta-Catenin Signaling in Oral Carcinogenesis
(MDPI, 2020)
Oral carcinogenesis is a complex and multifactorial process that involves cumulative
genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair
and defective cell death. At the ...
Simvastatin modulates beta-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
(Polska Akad Nauk, 2018)
The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional antitumor treatments as chemo and radiotherapy. It ...
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1
(NATL ACAD SCIENCES, 2006-12-26)
Multiple phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic pepticles ...
Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end
(2015)
The key protein in the canonical Wnt pathway is beta-catenin, which is phosphorylated both in absence and presence of Wnt signals by different kinases. Upon activation in the cytoplasm, beta-catenin can enter into the ...
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells
(American Association for Cancer Research, 2012-02)
Purpose: To study Wnt/β-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the β-catenin-androgen receptor (AR) interaction. Experimental Design: We carried out β-catenin ...