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Metformin inhibits platelet-mediated ovarian cancer cell progression
(2016)
Introduction: Increased platelets count (thrombocytosis) is associated with poor patient
prognosis an in vitro Investigation has shown that platelets induce cancer cell survival and
dissemination. The anti-diabetic drug ...
Metformin inhibit the effect of platelets on promotion of ovarian cancer cells
(2015)
Introduction: An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor of bad prognosis and metastasis in patients with ovarian cancer. The antidiabetic drug Metformin has been ...
Metformin reduces platelet-increased angiogenesis
(2015)
Introduction: Increased platelet number (Thrombocytosis) in cancer is correlated with poor prognostic. Platelets are known to increase angiogenesis, a process essential to cancer propagation. The anti-diabetic drug, ...
Metformin in the treatment of polycystic ovary syndrome
(Bentham Science Publishers, 2008-08)
Polycystic ovary syndrome (PCOS) is one of the most frequent diseases that affects women in their reproductive age. The heterogeneity of PCOS makes not only the diagnosis but also the choice of an adequate treatment ...
Drugs commonly associated with weight change: A systematic review and meta-analysis
(Oxford University Press, 2015)
Context: Various drugs affect body weight as a side effect. Objective: We conducted this systematic review and meta-analysis to summarize the evidence about commonly prescribed drugs and their association with weight change. ...
Anti-inflammatory properties of antidiabetic drugs: a “promised land” in the COVID-19 era?
Inflammation is implicated in the development and severity of the coronavirus disease 2019
(COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when
uncontrolled, is also recognized as an ...
Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin
(2018-07-01)
Background: A potential association between obesity and prostate cancer has been proposed. Metformin, an antidiabetes drug, has antiproliferative effects being proposed for cancer treatment. However, under intense proliferative ...
Metformin and colorectal cancer
(Instituto de Histología y Embriología, 2021-08)
Colorectal cancer (CRC) is one of the main causes of cancer-related mortality in the developed world despite recent developments in detection and treatment. Several epidemiological studies indicate that metformin, a widely ...
Metformin for the treatment of breast cancer: Protocol for a scoping review of randomised clinical trials
(2021-08-09)
Introduction Innovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic ...