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A conjugate of the lytic peptide Hecate and gallic acid: structure, activity against cervical cancer, and toxicity
(Springer, 2015-07-01)
Conjugate compounds constitute a new class of molecules of important biological interest mainly for the treatment of diseases such as cancer. The N-terminus region of cationic peptides has been described as important for ...
Lessons from a single amino acid substitution: anticancer and antibacterial properties of two phospholipase A2-derived peptides.
(2022)
The membrane-active nature of phospholipase A2-derived peptides makes them potential candidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA2 toxins ...
Effect of the aspartic acid D2 on the affinity of Polybia-MP1 to anionic lipid vesicles
(Springer, 2014-05-01)
Polybia-MP1 (IDWKKLLDAAKQIL-NH2), a helical peptide extracted from the venom of a Brazilian wasp, has broad-spectrum antimicrobial activities without being hemolytic or cytotoxic. This peptide has also displayed anticancer ...
Highlights in peptide nanoparticle carriers intended to oral diseases
(Bentham Science Publ Ltd, 2015-01-01)
New biocompatible nanomaterials are leading to a range of emerging health treatments. Thus, peptide drugs present in oral diseases, such as caries, periodontal diseases and oral cancer, are highlighting into clinical ...
Cationic antimicrobial peptides inactivate shiga toxin-encoding bacteriophages
(Frontiers Media S.A., 2018)
Shiga toxin (Stx) is the principal virulence factor during Shiga toxin-producing Escherichia coli (STEC) infections. We have previously reported the inactivation of bacteriophage encoding Stx after treatment with chitosan, ...
Differential interactions of the antimicrobial peptide, RQ18, with phospholipids and cholesterol modulate its selectivity for microorganism membranes
(2021-09-01)
Background: Antimicrobial peptides (AMPs) are molecules with potential application for the treatment of microorganism infections. We, herein, describe the structure, activity, and mechanism of action of RQ18, an α-helical ...
Exploiting zebrafish xenografts for testing the in vivo antitumorigenic activity of microcin E492 against human colorectal cancer cells
(Frontiers Media, 2020)
One of the approaches to address cancer treatment is to develop new drugs not only to obtain compounds with less side effects, but also to have a broader set of alternatives to tackle the resistant forms of this pathology. ...
Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom
(2018-11-01)
Antimicrobial peptides have been extensively described as bioactive agents, mainly considering their selective toxicity towards bacteria but not to healthy mammalian cells. In past years, this class of compounds has been ...