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Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles
(Pergamon-Elsevier Science Ltd, 2012-11)
The ability of cells to acquire resistance to multiple pharmaceuticals, namely multidrug resistance (MDR), is often mediated by the over-expression of efflux transporters of the ATP-binding cassette (ABC) superfamily; e.g., ...
Control of Peptide Amphiphile Supramolecular Nanostructures by Isosteric Replacements
(American Chemical Society, 2021-08)
Supramolecular nanostructures with tunable properties can have applications in medicine, pharmacy, and biotechnology. In this work, we show that the self-assembly behavior of peptide amphiphiles (PAs) can be effectively ...
Activation of Ca2+-independent membrane-damaging activity in Lys49-phospholipase A(2) promoted by amphiphilic molecules
(Elsevier B.V., 2004-09-17)
Association of class-II phospholipase A(2) (PLA(2)) with aggregated phospholipid substrate results in elevated levels of the Ca2+-dependent hydrolytic activity. The Asp49 residue participates in coordination of the Ca2+ ...
Emergence of supramolecular order from combined linear amphiphilic and diphosphonate molecules
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE FÍSICAUFMG, 2021)
Interação de moléculas sintéticas anfifílicas catiônicas com modelos miméticos de biomembranas
(Universidade Federal de São Paulo (UNIFESP), 2018-09-27)
Bacterial infections represent a serious health problem, aggravated by the resistance of
these microorganisms to conventional antibiotic agents. Therefore, alternative treatments,
such as those based on antimicrobial ...
New details of assembling bioactive films from dispersions of amphiphilic molecules on titania surfaces
(2020-11-02)
Tailoring the surface properties of materials for biomedical applications is important to avoid clinical complications. Forming thin layers of amphiphilic molecules with apolar regions that facilitate attractive intermolecular ...
L-DOPA modulates the kinetics but not the thermodynamic equilibrium of TTA+ amphiphiles forming lyotropic nematic liquid crystals
(2020-04-17)
Lyotropic liquid crystals (LLCs) are mixtures of amphiphile molecules usually studied as mimetic of biological membrane. The equilibrium dynamics of tetradecyltrimethyl ammonium cation (TTA+) molecules forming nematic LLCs ...
First-order phase transition during displacement of amphiphilic biomacromolecules from interfaces by surfactant molecules
(IOP Publishing, 2014-11)
The adsorption of surfactants onto a hydrophobic interface, already laden with a fixed number of amphiphilic macromolecules, is studied using the self consistent field calculation method of Scheutjens and Fleer. For ...
An ultraviolet photoacoustic spectroscopy study of the interaction between Lys49-phospholipase A(2) and amphiphilic molecules
(Elsevier B.V., 2007-02-23)
We have used near ultraviolet photoacoustic spectroscopy (PAS) over the wavelength range 240-320 nm to investigate the complex formed between the homodimeric bothropstoxin-I, a lysine-49-phospholipase A(2) from the venom ...
An ultraviolet photoacoustic spectroscopy study of the interaction between Lys49-phospholipase A(2) and amphiphilic molecules
(Elsevier B.V., 2007-02-23)
We have used near ultraviolet photoacoustic spectroscopy (PAS) over the wavelength range 240-320 nm to investigate the complex formed between the homodimeric bothropstoxin-I, a lysine-49-phospholipase A(2) from the venom ...