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A SequenceSpace analysis of Lys49 phospholipases A2: Clues towards identification of residues involved in a novel mechanism of membrane damage and in myotoxicity
(1998-04-01)
'SequenceSpace' analysis is a novel approach which has been used to identify unique amino acids within a subfamily of phospholipases A2 (PLA2) in which the highly conserved active site residue Asp49 is substituted by Lys ...
High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2001)
GibbsCluster: unsupervised clustering and alignment of peptide sequences
(Oxford University Press, 2017-04)
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and ...
A lipocalin sequence signature modulates cell survival
(ELSEVIER SCIENCE BV, 2010)
Lipocalins are beta-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs ...
Sequencing, bioinformatic characterization and expression pattern of a putative amino acid transporter from the parasitic cestode Echinococcus granulosus
(ELSEVIER, 2008-03-31)
We have sequenced and partially characterized an Echinococcus granulosus cDNA, termed egat1, from a protoscolex signal sequence trap (SST) cDNA library. The isolated 1627 bp long cDNA contains an ORF of 489 amino acids and ...
Charged amino acid motifs flanking each extreme of the αM4 transmembrane domain are involved in assembly and cell-surface targeting of the muscle nicotinic acetylcholine receptor
(Wiley-liss, Div John Wiley & Sons Inc, 2007-02-27)
The αM4 transmembrane domain of the nicotinic acetylcholine receptor (AChR) is flanked by two basic amino acids (His408 and Arg429) located at its cytoplasmic‐ and extracellular‐facing extremes, respectively, at the level ...
Antibodies to yeast Sm motif 1 cross-react with human Sm core polypeptides
(Blackwell Science, 2014)