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A Comparative Structural Analysis Reveals Distinctive Features Of Co-factor Binding And Substrate Specificity In Plant Aldo-keto Reductases
(Academic Press Inc Elsevier ScienceSan Diego, 2016)
A Comparative Structural Analysis Reveals Distinctive Features Of Co-factor Binding And Substrate Specificity In Plant Aldo-keto Reductases
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2016)
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi
(Wiley Blackwell Publishing, Inc, 2017-12)
The improvement of Chagas disease treatment is focused not only on the development of new drugs but also in understanding mechanisms of action and resistance to drugs conventionally used. Thus, some strategies aim to detect ...
Trypanosoma cruzi: Death phenotypes induced by ortho-naphthoquinone substrates of the aldo-keto reductase (TcAKR). Role of this enzyme in the mechanism of action of β-lapachone
(Cambridge University Press, 2018-02)
Several ortho-naphthoquinones (o-NQs) have trypanocidal activity against Trypanosoma cruzi, the aetiological agent of Chagas disease. Previously, we demonstrated that the aldo-keto reductase from this parasite (TcAKR) ...