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The role of high mobility group box 1 protein (HMGB1) in the immunopathology of experimental pulmonary tuberculosis
(Public Library of Science, 2015-07)
Background: The high mobility group box 1 (HMGB1) is the prototype of alarmin protein released by stressed or dying cells. The redox state of this protein confers different functions in the regulation of inflammation and ...
Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis
(2022)
Although vitamin D (VD) is known to have multiple effects on the skin and immunity, its effects on atopic dermatitis (AD) severity remain unclear. We investigated whether oral cholecalciferol (VD3) supplementation changes ...
Galectins as Danger Signals in Host–Pathogen and Host–Tumor Interactions: New Members of the Growing Group of “Alarmins”?
(Wiley, 2009)
Nearly 30 years passed since several glycobiology laboratories independently found that various cell extracts contained soluble b-galactoside-binding proteins (1–19). As all mammalian lectins are either released through ...
Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal–fetal infammation in mice
(2022)
Background: One of every four preterm neonates is born to a woman with sterile intra-amniotic inflammation (inflammatory process induced by alarmins); yet, this clinical condition still lacks treatment. Herein, we utilized ...
Advanced-glycation end-products axis: a contributor to the risk of severe illness from COVID-19 in diabetes patients
(Baishideng Publishing Group, Estados Unidos, 2021)
Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory ...
Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?
(Baishideng Publishing Group, 2021)
Compelling evidence supports the crucial role of the receptor for advanced
glycation end-products (RAGE) axis activation in many clinical entities. Since the
beginning of the coronavirus disease 2019 pandemic, there is ...
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
(TAYLOR & FRANCIS LTD, 2011)
Objective: Preterm parturition is a syndrome caused by multiple etiologies. Although intra-amniotic infection is causally linked with intrauterine inflammation and the onset of preterm labor, other patients have preterm ...