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GASS-WEB: a web server for identifying enzyme active sites based on genetic algorithms
(Oxford Journals, 2018)
The bactericidal effect of human secreted group IID phospholipase A(2) results from both hydrolytic and non-hydrolytic activities
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012)
The Human Secreted Group IID Phospholipase A(2) (hsPLA2GIID) may be involved in the human acute immune response. Here we have demonstrated that the hsPLA2GIID presents bactericidal and Ca2+-independent liposome membrane-damaging ...
Algoritmos genéticos para identicação de sítios ativos em enzimas
(Universidade Federal de Minas GeraisUFMG, 2015-03-30)
Currently, 25% of proteins annotated in the Protein Families Database (Pfam) have their function unknown. Experimental tests are expensive and time-consuming, and research has shown that the function of a protein can be ...
Outside-binding site mutations modify the active site's shapes in neuraminidase from influenza A H1N1
(Wiley, 2013)
The recent occurrence of 2009 influenza A (H1N1) pandemic as well as others has raised concern of a far more dangerous outcome should this virus becomes resistant to current drug therapies. The number of clinical cases ...
Reproductive site selection in the leaf-frog Phyllomedusa azurea Cope, 1862 (Anura: Hylidae) in altered areas of the Brazilian Cerrado
(Taylor & Francis Ltd, 2014-11-25)
The selection of reproductive sites by anurans may be associated with each species' behavioural restrictions, reproductive modes, morphology and physiology. We investigated the use of reproductive sites by Phyllomedusa ...