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Securinine derivatives as potential anti-amyloid therapeutic approach
(Bentham Science Publishers B.V., 2017)
Proinflammatory stimuli are needed for induction of microglial cell-mediated A beta PP244-C and A beta-neurotoxicity in hippocampal cultures
(IOS PRESS, 2008)
Amyloid-beta plaques and neurodegeneration are hallmarks of Alzheimer's disease, where glial cells are responsible for sustained neuroinflammation. Here we show that hippocampal-microglia co-cultures exposed to proinflammatory ...
Charge regulation phenomenon predicted from the modeling of polypeptide electrophoretic mobilities as a relevant mechanism of amyloid-beta peptide oligomerization
(Wiley VCH Verlag, 2016-03)
Electrophoretic mobilities of amyloid-beta (1-40) and (1-42) peptides and their aggregates are modeled to study the amyloidogenic pathway associated with Alzheimer´s Disease. The near molecule pH generated by the intraparticle ...
Commentary: Evidence for human transmission of amyloid-beta pathology and cerebral amyloid angiopathy
(Frontiers Media Sa, 2016)
Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Catalytic amyloids as novel synthetic hydrolases
(MDPI, 2021)
Amyloids are supramolecular assemblies composed of polypeptides stabilized by an intermolecular beta-sheet core. These misfolded conformations have been traditionally associated with pathological conditions such as Alzheimer's ...
Differential membrane toxicity of amyloid-beta fragments by pore forming mechanisms.
(2016)
A major characteristic of Alzheimer's disease (AD) is the presence of amyloid-beta peptide (A beta) oligomers and aggregates in the brain. It is known that A beta oligomers interact with the neuronal membrane and induce ...