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Mostrando ítems 11-20 de 297
ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma - Report of 10 cases
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2006)
Computational studies of TGF-ßRI (ALK-5) inhibitors |b analysis of the binding interactions between ligand–receptor using 2D and 3D techniques
(ElsevierAmsterdam, 2013-07)
ALK-5 (Activin-Like Kinase 5) is a biological receptor involved in a variety of pathological processes such
as cancer and fibrosis. ALK-5 receptor propagates an intracellular signaling that forms a protein complex
capable ...
Egfr and eml4-alk updated therapies in non-small cell lung cancer
(Amer Inst Physics, 2016)
Background: Non-small cell lung cancer is the leading cancer-related cause of death. Objective: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising ...
Lumican Peptides: Rational Design Targeting ALK5/TGFBRI
(Nature Publishing Group, 2017)
Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also functions as a matrikine regulating multiple cell activities. In the cornea, lumican maintains corneal transparency by ...
Mutation study of spanish patients with hereditary hemorrhagic telangiectasia and expression analysis of endoglin and ALK1
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant and age-dependent vascular disorder originated by mutations in Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes. The first large ...
Functional Analysis of saxophone, the Drosophila Gene Encoding the BMP Type I Receptor Ortholog of Human ALK1/ACVRL1 and ACVR1/ALK2
(GENETICS SOC AM, 2009)
In metazoans, bone morphogenetic proteins (BMPS) direct a myriad of developmental and adult homeostatic evens through their heterotetrameric type I and type II receptor complexes. We examined 3 existing and 12 newly generated ...
Utilidad de la expresión del marcador inmunohistoquimico ALK en pacientes con diagnóstico de linfoma no Hodgkin
(PUCE, 2016)
Los linfomas constituyen un grupo heterogéneo de entidades linfoproliferatívas con diversos
patrones de comportamiento clínico, biológico y de respuesta al tratamiento. La incidencia y
prevalencia de esta enfermedad en ...
Concordance analysis of ALK gene fusion detection methods in patients with Non– Small-Cell Lung Cancer from Chile, Brazil, and Peru
(2021-06)
About 4 to 7 % of the Non-small cell lung cancer patients have ALK rearrangements and specific target therapies improve patients’ outcomes significantly. ALK gene fusions are detected by immunohistochemistry (IHC) or ...
Expressão de miostatina, ActRIIB, ALK4 e folistatina em músculo esquelético e tecidos adiposos de ratos diabéticos submetidos ao exercício de natação
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Fisioterapia - PPGFt, 2011-05-11)
Introduction: Myostatin (MSTN), a member of TGF-β family, is characterized as a negative regulator of muscle mass and is present in small quantities in adipose tissue. Accumulating evidences suggest its participation ...