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DNA oxidation, strand-breaks and etheno-adducts formation promoted by Cu, Zn-superoxide dismutase-H(2)O(2) in the presence and absence of bicarbonate
(ROYAL SOC CHEMISTRY, 2009)
Biomolecule oxidation promoted by Cu, Zn-superoxide dismutase (SOD1) has been studied because of its potential role in neurodegenerative diseases. We studied the mechanism of DNA damage promoted by the SOD1-H(2)O(2) system. ...
Lipid hydroperoxide-induced and hemoglobin-enhanced oxidative damage to colon cancer cells
(ELSEVIER SCIENCE INC, 2011)
Epidemiological studies have indicated that Western diets are related to an increase in a series of malignancies. Among the compounds that are credited for this toxic effect are heme and lipid peroxides. We evaluated the ...
Effect of some antioxidants on oxidative DNA damage induced by autoxidation of microquantities of sulfite in the presence of Ni(II)/Gly-Gly-L-His
(TAYLOR & FRANCIS LTD, 2010)
Ni(II)GGH (GGH, glycylglycyl-L-histidine) reacts rapidly with S(IV), in air-saturated solution, to produce Ni(III)GGH. A mechanism is proposed where Ni(III) oxidizes SO(3)(2-) to SO(3)(center dot-), which reacts with ...
Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet
(Sage Publications Ltd, 2008-11)
Highly purified rat-liver nuclei were previously shown to have nuclear ethanol (EtOH) metabolizing system able to bioactivate alcohol to acetaldehyde and 1-hydroxyethyl radicals. These reactive metabolites were able to ...
Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial membrane induced by Fe2+-citrate
(Academia Brasileira de Ciências, 2006-09-01)
Iron imbalance/accumulation has been implicated in oxidative injury associated with many degenerative diseases such as hereditary hemochromatosis, beta-thalassemia, and Friedreich's ataxia. Mitochondria are particularly ...
Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS
(ELSEVIER SCIENCE BV, 2010)
Mutations in the gene encoding cytosolic Cu,Zn-superoxide dismutase (SOD1) have been linked to familial amyotrophic lateral sclerosis (FALS). However the molecular mechanisms of motor neuron death are multifactorial and ...
Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial membrane induced by Fe2+-citrate
(Academia Brasileira de Ciências, 2006)
Estudo de pré-formulação e formulação farmacêutica de uso tópico contendo Immucillin-DI4G como alternativa terapêutica para o tratamento da Leishmaniose Cutânea
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2016)
Introduction: Cutaneous leishmaniasis is caused by Leishmania protozoan and transmitted through the female of Lutzomyia sandflies. The disease can manifest itself in different clinical forms: localized cutaneous leishmaniasis, ...