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GABAA receptor family: overview on structural characterization
(Future Science, 2019-02-25)
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, ...
Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs
(Elsevier, 2008-01)
Three analogs of neuroactive steroids were prepared (4–6) in which 1,11- or 11,19-oxygen bridges give a constrained conformation. Their 3D structures were obtained by ab initio calculations and in the case of 3α-hydroxy- ...
The availability of surface GABAB receptors is independent of γ-aminobutyric acid but controlled by glutamate in central neurons
(2008)
The efficacy of synaptic transmission depends on the availability of ionotropic and metabotropic neurotransmitter receptors at the plasma membrane, but the contribution of the endocytic and recycling pathways in the ...
Synthesis and GABA(A) receptor activity of oxygen-bridged neurosteroid analogs
(2008)
Three analogs of neuroactive steroids were prepared (4-6) in which 1,11- or 11,19-oxygen bridges give a constrained conformation. Their 3D structures were obtained by ab initio calculations and in the case of 3 ...
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus
(Oxford Univ Press Inc, 2014-06-01)
The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial ...
Dendritic assembly of heteromeric γ-aminobutyric acid type B receptor subunits in hippocampal neurons
(2009)
Understanding the mechanisms that control synaptic efficacy through the availability of neurotransmitter receptors depends on uncovering their specific intracellular trafficking routes. γ-Aminobutyric acid type B (GABAB) ...
The availability of surface gaba(b) receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neuronsJOURNAL OF BIOLOGICAL CHEMISTRY
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2016)