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Estudio in silico e in in vitro de compuestos inhibidores de la enzima lipasa pancreática: una contribución al reposicionamiento de fármacos antiobesidad
(2016)
La obesidad es una enfermedad que afecta a más de 650 millones de personas en el mundo. Se origina por la acumulación excesiva de grasa en el organismo. Aunque su tratamiento farmacológico es una de las alternativas más ...
Estudo pré-clínico dos fármacos letrozol e pamidronato como alternativas terapêuticas para tratamento da leishmaniose visceral humana
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-01-29)
Visceral leishmaniasis (VL) is an infectious disease caused in Brazil by the species Leishmania
(Leishmania) infantum and, currently, there are no vaccines and/or prophylactic therapies for
VL in humans, and the ...
Avaliação da atividade antiamebiana de compostos presentes no Covid-Box® contra trofozoítos de Acanthamoeba castellanii
(Florianópolis, SC, 2021-09-21)
Free-living amoebas are ubiquitous protozoa that can be isolated from various
environmental niches, such as soil, water and vegetation. The genus Acanthamoeba
spp. has the characteristic of being amphizoic amoebas, ...
Methods to Investigate signal transduction pathways in Trypanosoma cruzi: Cyclic nucleotide phosphodiesterases assay protocols
(Springer, 2020)
Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fact, ...
Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
(Elsevier Ireland, 2020-09)
In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture ...
Exploring solid forms of oxytetracycline hydrochloride
(Elsevier Science, 2020-07-30)
Oxytetracycline hydrochloride, an antibiotic of the tetracycline family, is a polymorphic drug that evidences erratic absorption in oral administration. Additionally, poor solid state characterization of the polymorphs and ...
Atividades da nicotinamida, do ácido nicotínico e do nicorandil em modelos experimentais de inflamação articular: uma avaliação visando ao reposicionamento de fármacos
(Universidade Federal de Minas GeraisUFMG, 2016-07-27)
Inflammatory joint diseases such as rheumatoid arthritis (RA), osteoarthritis (OA) and gout are chronic painful conditions that limit the quality of life of patients, whose importance increases with the population ageing ...
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells
(2019)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with ...
Stairway to Heaven or Hell? Perspectives and Limitations of Chagas Disease Chemotherapy
(Bentham Science Publishers, 2017)