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Mostrando ítems 161-170 de 321
Doença pulmonar obstrutiva crônica
(2004-12-01)
The chronic obstructive lung disease is reviewed with emphasys on its epidemiology and risk factors. The diagnosis, clinical aspects pulmonary, functional alterations and laboratorial findings are discussed. The treatment ...
Caracterização de osteoblastos diferenciados de células-tronco mesenquimais da medula óssea de ratos espontâneamente hipertensos (SHR)
(Universidade Estadual Paulista (Unesp), 2014-08-26)
Hypertension is a systemic risk factor for several diseases including reduction of bone mass by increasing bone resorption and reducing bone formation. Considering that bone formation results from osteoblast activity, the ...
Issues in drug metabolism of major antihypertensive drugs: β-blockers, calcium channel antagonists and angiotensin receptor blockers
(Taylor & Francis, 2010-01)
Several first-line antihypertensive drugs, including calcium channel blockers, beta-adrenergic blockers and angiotensin receptor blockers, undergo metabolism through different CYP isoforms. As a consequence of CYP-dependent ...
Participación de Kisspeptina en el reclutamiento folicular durante el envejecimiento ovárico
(Universidad de Chile, 2016)
En la actualidad las parejas deciden postergar la maternidad más allá de los 30 años de edad, acercándose a la ventana de subfertilidad de la mujer. Este cambio en la conducta de la población disminuye la probabilidad de ...
Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch
(2017-07-01)
The skeleton is a common site for breast cancer metastasis. Although significant progress has been made to manage osteolytic bone lesions, the mechanisms driving the early steps of the bone metastatic process are still not ...
Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form
(American Society For Biochemistry And Molecular Biology, 2010-05-14)
The idea of G protein-coupled receptors (GPCRs) coupling to G protein solely in their active form was abolished when it was found that certain ligands induce a G protein-coupled but inactive receptor form. This receptor ...
Efecto del estrés gestacional sobre los cambios en los receptores [beta]-adrenérgicos cardíacos durante el desarrollo de ratas hembras y sus consecuencias a nivel cardiovascular y metabólico
(Universidad de Chile, 2016)
El estrés está definido como cualquier estímulo capaz de alterar la homeostasis del organismo, es una reacción fisiológica necesaria para la supervivencia y es la forma que posee el organismo para afrontar una situación ...
Estudo do efeito modulador da noradrenalina e sinalização via receptor adrenérgico "2 sob a replicação do hiv-1 em linfócitos tcd4+ primários não ativados
(Universidade Federal de São Paulo (UNIFESP), 2018-05-15)
The human immunodeficiency virus (HIV1)
has been a constant target of research for
being the causative agent of a yet incurable disease – the acquired immunodeficiency
syndrome (AIDS). Currently, latency is one of main ...