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Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
(Faculdade de Medicina / USP, 2010-01-01)
OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years ...
Hemodynamic effects of combined sildenafil and L-arginine during acute pulmonary embolism-induced pulmonary hypertension
(Elsevier Science BvAmsterdamHolanda, 2005)
TISs-ST: a web server to evaluate polymorphic translation initiation sites and their reflections on the secretory targets
(Biomed Central LtdLondonInglaterra, 2007)
Hemodynamic effects of combined sildenafil and L-arginine during acute pulmonary embolism-induced pulmonary hypertension
(Elsevier B.V., 2005-11-07)
Sildenafil attenuates acute pulmonary embolism-induced pulmonary hypertension. However, the hemodynamic effects of sildenafil in combination with other vasodilators during acute pulmonary embolism have not been examined ...
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway
(Frontiers Research Foundation, 2015-03-25)
G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their ...
8-NH2-boldine, an antagonist of α1A and α1B adrenoceptors without affinity for the α1D subtype: Structural requirements for aporphines at α1- adrenoceptor subtypes
(2005)
Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human α1A, α1B and α1D adrenoceptors (AR) using membranes prepared from rat-1 fibroblasts stably expressing ...
Regulation of intracellular cyclic AMP in skeletal muscle cells involves the efflux of cyclic nucleotide to the extracellular compartment
(Nature Publishing Group, 2003-03-01)
1 This report analyses the intracellular and extracellular accumulation of cyclic AMP in primary rat skeletal muscle cultures,. after direct and receptor-dependent stimulation of adenylyl cyclase (AC).2 Isoprenaline, ...
Atypical beta-adrenoceptor subtypes mediate relaxations of rabbit corpus cavernosum
(Amer Soc Pharmacology Experimental TherapeuticsBethesdaEUA, 2004)