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Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
(National Academy of Sciences, 2017-01)
Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates ...
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs
(American Physiological Society, 2013)
We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at high altitude (HA, 3,600 ...
Participación de los canales TRPC-ORAI activados por STIM (STOC) en la hipertensión pulmonar inducida por hipoxia intermitente crónica
(2022)
La apnea obstructiva del sueño (AOS), un trastorno de la respiración durante el sueño caracterizado por la hipoxia intermitente (CIH), se asocia con hipertensión sistémica y pulmonar (HP). Se ha demostrado que la hipoxia ...
MUTAGENESIS AND TEMPERATURE-SENSITIVE LITTLE MACHINES
(INTECH, 2012)
In mammals a class of ion channels able to sense a wide range of temperatures (0-60 °C) has evolved. These molecular thermodynamic machines called thermo Transient Receptor Potential (thermoTRP) are spread through the ...
Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice
(Amer Physiological SocBethesdaEUA, 2011)