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The hydrophobic mismatch determines the miscibility of ceramides in lipid monolayers
(Elsevier Ireland, 2012-09)
The organization of lipids within membranes strongly depends on the interaction with other lipid and protein molecules. Sphingolipids comprise a structurally diverse family, the ceramides being some of the simplest members. ...
Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors
(Association for Research in Vision and Ophthalmology, 2009-09)
PURPOSE. Identifying the cues required for survival and development of photoreceptors is essential for treating retina neurodegenerations. We previously established that glial derived neurotrophic factor (GDNF) stimulates ...
Laurdan generalized polarization fluctuations measures membrane packing micro-heterogeneity in vivo
(National Academy of Sciences, 2012-05)
Cellular membranes are heterogeneous in composition, and the prevailing theory holds that the structures responsible for this heterogeneity in vivo are small structures (10–200 nm), sterol- and sphingolipid-enriched, of ...
Fluorescence sensors for imaging membrane lipid domains and cholesterol
(Elsevier Academic Press Inc., 2021-10)
Lipid membrane domains are supramolecular lateral heterogeneities of biological membranes. Of nanoscopic dimensions, they constitute specialized hubs used by the cell as transient signaling platforms for a great variety ...
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity
(American Society for Biochemistry and Molecular Biology, 2015-04)
Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization. Particularly, SM is associated ...
A metabolic circadian clock controls rhythms in immortalized human glioblastoma T98G cells
(Tech Science Press, 2016)
Rat spermatogenic cell membranes contain sphingolipids with nonhydroxy and 2-hydroxy very long chain (C24-32) PUFA. The biosynthesis of such fatty acids requires the expression of very long chain fatty acid elongases (Elovl4 ...
Estudo de monocamadas fosfolipidicas nanoestruturadas obtidas por LB para aplicações em biossensores
(Universidade Federal de Minas GeraisUFMG, 2007-02-16)
There has been long-standing interest in the physical chemical properties of defined mixtures of cholesterol and phospholipids in monolayer and bilayer membranes. They also provide insight into certain properties of the ...
Uma abordagem metabolômica em pacientes com Leucemia Linfocítica Crônica e Sìndrome Mielodisplásica
(Universidade Federal de Minas GeraisUFMG, 2018-06-14)
Chronic Lymphocytic Leukemia (CLL) and Myelodysplastic Syndrome (MDS) are hematological malignancies that result in quantitative and qualitative changes in blood cells. In CLL, neoplastic cells (B lymphocytes) accumulation ...
Fluorescence sensors for imaging membrane lipid domains and cholesterol
(Academic Press, 2021)
Abstract:
Lipid membrane domains are supramolecular lateral heterogeneities of biological membranes. Of nanoscopic dimensions, they constitute specialized hubs used by the cell as transient signaling platforms for a great ...
Role of Annexin A1 in NLRP3 Inflammasome Activation in Murine Neutrophils
(2021-01-11)
This study evaluated the role of endogenous and exogenous annexin A1 (AnxA1) in the activation of the NLRP3 inflammasome in isolated peritoneal neutrophils. C57BL/6 wild-type (WT) and AnxA1 knockout mice (AnxA1-/-) received ...