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Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients
(Harvard Medical School, 2016-03-10)
Several epidemiological studies in diabetic patients have demonstrated a protective effect
of metformin to the development of several types of cancer. The underlying mechanisms of
such phenomenon is related to the effect ...
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats
(Elsevier B.V., 2018-05-01)
Purpose: We investigated the influence of diabetes mellitus (DM), glycemic control with insulin, cimetidine (Oct2 inhibitor) and metformin (Oct2 substrate) on the kinetic disposition of GAB in rats. Main methods: Male ...
Treatment With Metformin Improves Erectile Dysfunction In A Murine Model Of Obesity Associated With Insulin Resistance
(ELSEVIER SCIENCE INCNEW YORK, 2015)
Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice
(Csiro Publishing, 2006-12)
The present study examined the mechanism by which metformin prevents dehydroepiandrosterone (DHEA)-induced embryonic resorption in mice. Treatment with DHEA (6 mg/100 g bodyweight, 24 and 48 h post implantation) induced ...
Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone
(BioScientifica, 2006-03)
The present study investigated the role of the N, N{ 0 }-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by ...