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Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids
(American Chemical Society, 2021-08-04)
Cell-penetrating peptides (CPPs) are a topic subject potentially exploitable for creating new nanotherapeutics for the delivery of bioactive loads. These compounds are often classified into three major categories according ...
Antibacterial and antitumorigenic properties of microcin E492, a poreforming bacteriocin
(2009)
Microcins are a family of low-molecular weight bacteriocins produced and secreted by Gram-negative bacteria. This review is focused on microcin E492, a pore-forming bacteriocin produced by Klebsiella pneumoniae RYC492 that ...
Effects Of Novel Acylhydrazones Derived From 4-quinolone On The Acetylcholinesterase Activity And A Beta 42 Peptide Fibrils Formation
(Taylor & Francis LtdAbingdon, 2016)
The key role of membranes in amyloid formation from a biophysical perspective
(Bentham Science Publishers, 2011-05)
Even though our knowledge of how proteins misfold and aggregate is deeper nowadays, the mechanisms driving this process are still poorly understood. Among the factors involved, membranes should be taken into account. Indeed, ...
Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis
(SPRINGER, 2008-11)
Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome
(ELSEVIER, 2010)
Human Down syndrome (DS) represents the most frequent cause of mental retardation associated to
a genetic condition. DS also exhibits a characteristic early onset of neuropathology indistinguishable
from that observed ...
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
(Sociedad de Biología de Chile, 2008)
Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic Vesicles
(Public Library Science, 2016)
In contrast to vertebrate immune systems, invertebrates lack an adaptive response and rely solely on innate immunity in which antimicrobial peptides (AMPs) play an essential role. Most of them are membrane active molecules ...
Neuroimaging in Alzheimer's disease: current role in clinical practice and potential future applications
(Faculdade de Medicina / USP, 2011)
'Alzheimer's disease is the most common cause of dementia and its prevalence is expected to increase in the coming years. Therefore, accurate diagnosis is crucial for patients, clinicians and researchers. Neuroimaging ...