Buscar
Mostrando ítems 1321-1330 de 1982
Chalcone derivatives 4′-amino-1-naphthyl-chalcone (D14) and 4′-amino-4-methyl-1-naphthyl-chalcone (D15) suppress migration and invasion of osteosarcoma cells mediated by p53 regulating emt-related genes
(2018-09-19)
Osteosarcoma (OS) is a primary malignant bone tumor that mainly affects children, adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy since the development of metastatic disease due ...
Lupeol, a pentacyclic triterpene, promotes migration, wound closure, and contractile effect in vitro: Possible involvement of PI3K/Akt and p38/ERK/MAPK pathways
(2018-10-30)
Skin wound healing is a dynamic and complex process involving several mediators at the cellular and molecular levels. Lupeol, a phytoconstituent belonging to the triterpenes class, is found in several fruit plants and ...
Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering
(2021-07-01)
The skin serves a substantial number of physiological purposes and is exposed to numerous biological and chemical agents owing to its large surface area and accessibility. Yet, current skin models are limited in emulating ...
Role of the TNF-α receptor type 1 on prostate carcinogenesis in knockout mice
(2016-07-01)
BACKGROUND: TNF-α is a key cytokine involved in prostate carcinogenesis and is mediated by the TNF-α receptor type 1 (TNFR-1). This receptor triggers two opposite pathways: cell death or cell survival and presents a ...
Metabolic effects of CoCr-enriched medium on shear-stressed endothelial cell and osteoblasts: A possible mechanism involving a hypoxic condition on bone healing
(2021-09-01)
Cobalt-chromium (CoCr)-based alloys have emerged as an interesting biomaterial within biomedical field, mainly considering their biocompatibility, resistance to corrosion and absence of magnetism; however, its effect on ...
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines
(Elsevier, 2011-02)
Neutrophil collagenase or collagenase-2 (matrix metalloproteinase [MMP]-8) belongs to the collagenase
subgroup of the MMP superfamily of calcium- and zinc-dependent neutral proteinases. MMP-8 is catalytically
the most ...
Selenoprotein hydrolysates from chickpea (Cicer arietnum L.) as a cosmeceutical ingredient
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-06-15)
Skin aging represents a health problem due to the decreased protection function of the skin which leads to cuts and slow wound healing capacity, resulting in infections and skin diseases from dermatitis to skin cancer. ...
Silenciamento do gene itgb3 de células de tumor de mama murino triplo negativo (4T1BM2)
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosBiotecnologia - Biotec, 2022-09-14)
Breast cancer is the most recurrent type of tumor in the world, surpassing lung cancer, according to data published in 2021 by the World Health Organization (WHO). When tumor cells spread or invade nearby or distant tissues, ...
Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis
(2021-05)
The muscle regeneration process requires a properly assembled extracellular matrix (ECM). Its homeostasis depends on the activity of different matrix-metalloproteinases (MMPs). The reversion-inducing-cysteine-rich protein ...