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Mostrando ítems 121-130 de 266
Propriedades termofísicas e de agregação de líquidos iônicos dianiônicos derivados de ácidos carboxílicos
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2020-03-25)
Ionic Liquids (ILs) have been considered good candidates for thermal storage materials due to their properties of thermal stability, non-flammability, low volatility, low corrosion and high heat capacity. Dicationic ILs ...
Sensibility of evaluations of malassezia furfur strains at cyclic imides Avaliação da sensibilidade de cepas de malassezia furfur a imidas cíclicas
(2002)
Malassezia furfur (Pityrosporum orbiculare) is a lipophilic microrganism and it has also been associated with pityriasis versicolor, folliculitis, seborrheic and atopic dermatitis, fungemia and systemic infections. The ...
Adrenal Rest Tumor of the Liver Causing Cushing’s Syndrome: Treatment withKetoconazole preceding an Apparent Surgical Cure
(1985)
Ketoconazole, an imidazole derivative known to inhibit cytochrome P450-dependent adrenal enzymes was given to a patient with a functioning adrenal rest tumor of the liver in preparation for surgery. The drug was administered ...
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism
(1988)
A new generation of heteroatom analogs of arachidonic acid are documented as powerful and selective inhibitors of the cytochrome P-450-dependent arachidonic acid oxygenase reaction (IC50, 5-10 μm) with little effect on ...
Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity
(Elsevier France-editions Scientifiques Medicales Elsevier, 2017-01)
In this work, the synthesis of a series of 2-arylazoimidazole derivatives 6–20 has been achieved through the reaction of imidazole with aryldiazonium salts, followed by ultrasound-assisted alkylation. This approach has ...
Suitable multicomponent organic synthesis using heteropolycompounds as catalysts
(Bentham Science Publishers, 2015-04)
Nowadays, scientists need to work with non-contaminating technologies. Some approaches include the use of multicomponent reactions (MCRs), and solid and reusable catalysts. Through MCRs it is possible to work without ...
Immobilized boronic acid for Suzuki-Miyaura coupling: Application to the generation of pharmacologically relevant molecules
(Royal Society of Chemistry, 2017-07)
An synthetic strategy for the generation of a variety of biaryl and related derivatives, based on Suzuki-Miyaura coupling using immobilized boronic acid, is described. The importance of the methodology was demonstrated by ...
Mecanismo de ação e toxicidade da anfotericina B no tratamento de micoses
(Universidade Federal de Minas GeraisUFMG, 2011-01-01)
The main commercially available antifungal agents have similar mechanisms of action and the main target of these compounds is represented by the fungal cell membrane sterols. Although numerous studies focusing on the ...
Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
(2009-05-01)
Ketoconazole is a synthetic broad-spectrum oral and topical antifungal drug derived from imidazole, effective in the treatment of superficial mycoses and systemic infections. In this study we have tested several methods ...