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Survival rates and tolerability of platinum-based chemotherapy regimens for elderly patients with non-small-cell lung cancer (NSCLC)
(Elsevier B.V., 2006-08-01)
Background: the combination therapy for non-small-cell lung cancer (NSCLC) with platinum-based treatment is well known, but its utility in elderly has not been explored systematically. Aim: To examine whether aging compromises ...
B16 melanoma cells increase B-1 cell survival, IL-10 production and radioresistance in vitro
(Elsevier B.V., 2013-04-01)
B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. the role of both cell populations ...
HNSCC subverts PBMCs to secrete soluble products that promote tumor cell proliferation
(Impact Journals Llc, 2017-09-05)
The immune system detects shifts from homeostasis and eliminates altered cells. However, neoplastic cells can modulate the host response to escape immunosurveillance thereby allowing tumor progression. Head and neck squamous ...
Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells
(American Chemical Society, 2013)
Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of ...
Productive infection of Piscirickettsia salmonis in macrophages and monocyte-like cells from rainbow trout, a possible survival strategy
(2009)
Piscirickettsia salmonis is the etiologic agent of the salmonid rickettsial septicemia (SRS), an endemic disease which causes significant losses
in salmon production. This intracellular bacterium is normally cultured in ...
FixL-like sensor FlbS of Brucella abortus binds haem and is necessary for survival within eukaryotic cells
(Elsevier Science, 2013-08-14)
Replication of Brucella inside eukaryotic cells is essential for pathogenesis, and successful infection requires rapid adaptation to the intracellular milieu. Close relatives of Brucella use the two-component system FixLJ ...
A complexa fisiopatologia dos episódios vasooclusivos na anemia falciforme
(2002-12-01)
Hemolytic anemia and vasoocclusion are the cardinal clinical features of sickle cell anemia. Vasoocclusion is a complex process involving not only the polymerization of deoxygenated sickle hemoglobin tetramers, but also ...
A complexa fisiopatologia dos episódios vasooclusivos na anemia falciforme
(2002-12-01)
Hemolytic anemia and vasoocclusion are the cardinal clinical features of sickle cell anemia. Vasoocclusion is a complex process involving not only the polymerization of deoxygenated sickle hemoglobin tetramers, but also ...