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Influence of environmental parameters on mycotoxin production by Alternaria arborescens
(Elsevier Science, 2015-12-12)
Alternaria arborescens has been reported as a common fungal species invading tomatoes and is capable of producing several mycotoxins in infected plants, fruits and in agricultural commodities. Alternariol (AOH), alternariol ...
Parity-induced differential expression suggest a set of candidate ovarian cancer genes by estropausal age in mice
(2014)
Background: Ovarian cancer (OC) is the second leading cause of death from gynecological cancer in Chile. To date, OC etiology is controversial though reproductive history seems to play a significant role as relevant ...
Stratification of Sphingosine Kinase-1 Expression and Activity in Rat Kidney
(Karger, 2008-12)
Sphingosine-1-phosphate, the product of sphingosine kinase (SK) activity, is a sphingolipid metabolite that regulates cell growth, survival and migration. It is also known to affect diuresis, natriuresis and renovascular ...
Novel strategy in Trypanosoma cruzi cell invasion: Implication of cholesterol and host cell microdomains
(Elsevier B.V., 2007-11-01)
Trypanosoma cruzi, the etiological agent of Chagas' disease, is an obligatory intracellular parasite in the mammalian host. in order to invade a wide variety of mammalian cells, T cruzi engages parasite components that are ...
Ceramide induces a multicomponent intracellular calcium increase triggering the acrosome secretion in human sperm
(Elsevier Science, 2020-07)
Exocytosis of spermatozoon's secretory vesicle, named acrosome reaction (AR), is a regulated event that plays a central role in fertilization. It is coupled to a complex calcium signaling. Ceramide is a multitasking lipid ...
A necessary connection: cholesterol and nicotinic receptors
(Sociedad Argentina de Biofísica, 2019)
It is known that the muscle nicotinic acetylcholine receptor (nAChR) is highly influenced by its lipid environment. It is present in high-density clusters in the muscle cell membrane where it localizes mainly in liquid-ordered ...
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
(American Physiological Society, 2014-07)
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 ...
The lipidome in nonalcoholic fatty liver disease: Actionable targets
(American Society for Biochemistry and Molecular Biology, 2021-05)
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. Recent technological advances, combined with OMICs experiments and explorations involving different biological samples, have ...
Light, lipids and photoreceptor survival: live or let die?
(Royal Society of Chemistry, 2015-09)
Due to its constant exposure to light and its high oxygen consumption the retina is highly sensitive to oxidative damage, which is a common factor in inducing the death of photoreceptors after light damage or in retina ...
Dynamic microscopy: Reconstructing a novel lysosomal trafficking pathway
(Formatex Research Center, 2012)
The delivery of newly synthesized lysosomal proteins to endosomes and lysosomes is dependent on several functionally distinct compartments, i.e., the endoplasmic reticulum (ER), the Golgi apparatus and small carrier vesicles. ...