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Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep
(INT PEDIATRIC RESEARCH FOUNDATION, INC, 2008)
Perinatal exposure to chronic hypoxia induces sustained hypertension and structural and functional changes in the pulmonary vascular bed. We hypothesized that highland newborn lambs (HLNB, 3600 m) have a higher pulmonary ...
Multiple behavior phenotypes of the fragile - X syndrome mouse model respond to chronic inhibition of phosphodiesterase - 4D (PDE4D)
(Nature Publishing Group, 2017)
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent ...
Effect of sildenafil in cavernous arteries of patients with erectile dysfunction
(Sociedade Brasileira de Urologia, 2003-08-01)
INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction. The effect of sildenafil citrate in the cavernous arteries of ...
The Response of Cupriavidus metallidurans CH34 to Cadmium Involves Inhibition of the Initiation of Biofilm Formation, Decrease in Intracellular c-di-GMP Levels, and a Novel Metal Regulated Phosphodiesterase
(2019)
Cadmium is a highly toxic heavy metal for biological systems. Cupriavidus metallidurans CH34 is a model strain to study heavy metal resistance and bioremediation as it is able to deal with high heavy metal concentrations. ...
Sildenafil inhibits duodenal contractility via activation of the NO-K+ channel pathway
(BLACKWELL PUBLISHING, 2008)
Phosphodiesterase type-5 (PDE5) specifically cleaves cyclic guanosine monophosphate (cGMP), a key intracellular secondary messenger. The PDE5 inhibitor sildenafil is a well-known vasodilator that also has gastrointestinal ...
Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009)
Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent pro-apoptotic agent in Jurkat T cells inducing a complex phospholipase ...
Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation
(AMER SOC CELL BIOLOGY, 2010)
Endocytosis modulates EGFR function by compartmentalizing and attenuating or enhancing its ligand-induced signaling. Here we show that it can also control the cell surface versus intracellular distribution of empty/inactive ...
Synthesis and degradation of cAMP in Giardia lamblia: Possible role and characterization of a nucleotidyl cyclase with a single cyclase homology domain
(Portland Press, 2017-12)
Despite its importance in the regulation of growth and differentiation processes of a variety of organisms, the mechanism of synthesis and degradation of cAMP (cyclic AMP) has not yet been described in Giardia lamblia. In ...
Determination of sildenafil and vardenafil by capillary zone electrophoresis using capacitively coupled contactless conductivity detection
(2013-04-21)
A method based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) for determination of two important phosphodiesterase type-5 inhibitors (sildenafil and vardenafil) is ...
Determination of sildenafil and vardenafil by capillary zone electrophoresis using capacitively coupled contactless conductivity detection
(2013-04-21)
A method based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) for determination of two important phosphodiesterase type-5 inhibitors (sildenafil and vardenafil) is ...