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Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models
(Impact Journals LLC, 2017-01)
Discovery of new drugs for cancer treatment is an expensive and time-consuming process and the percentage of drugs reaching the clinic remains quite low. Drug repositioning refers to the identification and development of ...
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
(2021-01-01)
Background & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, ...
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation
(Universidade de São Paulo, Faculdade de Ciências FarmacêuticasDiseño y Formulación de Medicamentos Cosméticos y AfinesSao Paulo, Brasil, 2022)
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation
(Elsevier Ireland, 2020-11)
Skin exposure to ultraviolet B (UVB) radiation leads to local oxidative stress, inflammation, systemic immunosuppression and, ultimately, the development of skin cancer. Metformin is the most prescribed drug for type 2 ...
Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats
(Elsevier Science, 2011-10)
Long-term treatment with the insulin-sensitizer rosiglitazone reduces bone mass and increases fracture risk. We have recently shown that orally administered metformin stimulates bone reossification and increases the ...
Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
(Nature Publishing Group, 2019-02)
Hepatocellular carcinoma (HCC) is a highly metastatic cancer with very poor prognosis. AMP activated kinase (AMPK) constitutes a candidate to inhibit HCC progression. First, AMPK is downregulated in HCC. Second, glucose ...
Efecto de metformina sobre la expresión del factor de necrosis tumoral-a, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2
(2012)
Background: The pharmacological action of metformin goes beyond mere
glycemic control, decreasing markers of inflammation and contributing to the
reduction of oxidative stress. Aim: To evaluate biochemical, anthropometric ...
Avaliação das atividades da metformina em modelos experimentais de dores nociceptiva, inflamatória e neuropática e inflamação
(Universidade Federal de Minas GeraisUFMG, 2016-02-26)
Metformin is an oral hypoglycemic drug widely used to treat patients with type 2 diabetes. Although some studies have demonstrated that metformin exhibits anti-inflammatory activity, probably associated with inhibition of ...
Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome
(Wiley-Blackwell, 2014-01-01)
BackgroundThe use of insulin-sensitising agents, such as metformin, in women with polycystic ovary syndrome (PCOS) who are undergoing ovulation induction or in vitro fertilisation (IVF) cycles has been widely studied. ...