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Differential alterations of intracellular [Ca2+] dynamics induced by cocaine and methylphenidate in thalamocortical ventrobasal neurons
(Open Access Text, 2017-07)
The ventrobasal (VB) thalamus relay nucleus processes information from rodents? whiskers, projecting to somatosensory cortex. Cocaine and methylphenidate (MPH) have been described to differentially alter intrinsic properties ...
Alterações na linhagem celular e organização neuronal do giro denteado em dois modelos animais de epilepsia
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS, 2017-08-30)
The granular cells of the hippocampus are one of the few types of neurons generated in the central nervous system of adult mammals. The current model of neurogenesis in the adult hippocampus assumes that neural stem cells ...
Individual Differences In Amphetamine Sensitization: Role Of Dorsolateral StriatumDiferencias individuales en la sensibilización a anfetamina: Rol del estriado dorsolateral
(2020)
Clinical evidence shows that the development of drug addiction is not observed in all subjects. While differential changes in nucleus accumbens have been observed, is unknown whether modifications in other basal ganglia ...
Differential projections from the lateral habenula to the rostromedial tegmental nucleus and ventral tegmental area in the rat
(WILEY-BLACKWELLMALDEN, 2012)
The mesopontine rostromedial tegmental nucleus (RMTg) is a mostly ?-aminobutyric acid (GABA)ergic structure believed to be a node for signaling aversive events to dopamine (DA) neurons in the ventral tegmental area (VTA). ...
Gabapentin increases expression of δ subunit-containing GABA A receptors
(Elsevier, 2019)
Background: Gabapentin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its
anticonvulsant, analgesic and anxiolytic properties suggest that it increases GABAergic inhibition; however, ...
Avaliação do efeito do composto MPMT-OX sobre neurotransmissão e comportamento convulsivo em Caenorhabditis elegans
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2017-03-06)
Epilepsy is characterized as an increased predisposition of the brain to generate recurrent seizures, which represent the effects of abnormal, excessive and hypersynchronous electrical discharges of cortical neurons. ...
Sodium Potassium Chloride co-transporter 1 (NKCC1) is responsible of high excitability in chronic epilepsy in adult rats
(2015)
The increase in hippocampal excitability is one of the cardinal symptoms of temporal lobe epilepsy (TLE), the most common
epilepsy type. In epileptic patients as well as animal models have been observed an increase in ...
Chloride Co-Transporters In Neuropsychiatric Disorders
(2014)
GABA is the main inhibitory neurotransmitter in the nervous system, which opens Cl- selective channels.
Depending on the intracellular Cl- concentration, the ion flux could cause either inhibitory or excitatory
effects. ...
Excitotoxic neonatal damage induced by monosodium glutamate reduces several GABAergic markers in the cerebral cortex and hippocampus in adulthood
(2009)
Monosodium glutamate (MSG) administered to neonatal rats during the first week of life induces a neurodegenerative process, which is represented by several neurochemical alterations of surviving neurons in the brain, where ...