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Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005)
The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar beta-amyloid (A beta) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules ...
How Changes in the Sequence of the Peptide CLPFFD-NH2 Can Modify the Conjugation and Stability of Gold Nanoparticles and Their Affinity for B-Amyloid Fibrils
(American Chemical Society, 2008-05-30)
In a previous work, we studied the interaction of -amyloid fibrils (A ) with gold nanoparticles (AuNP) conjugated
with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the ...
Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
(Taylor and Francis Ltd, 2017)
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)
Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid
beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here
we report, the discovery ...
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)
Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid
beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here
we report, the discovery ...
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.
(2009)
BACKGROUND: The amyloid beta-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The intrinsic and external/environmental factors that determine ...