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Altered ROS production, NF-kappa B activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells
(Elsevier, 2015)
Duchenne muscular dystrophy is a fatal X-linked genetic disease, caused by mutations in the dystrophin gene, which cause functional loss of this protein. This pathology is associated with an increased production of reactive ...
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins
(Frontiers Research Foundation, 2015)
Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express ...
Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells
(Elsevier, 2015)
Duchenne muscular dystrophy is a fatal X-linked genetic disease, caused by mutations in the dystrophin gene, which
cause functional loss of this protein. This pathology is associated with an increased production of reactive ...
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease
(NATURE PUBLISHING GROUP, 2011)
Germline mutations in CYBB, the human gene encoding the gp91(phox) subunit of the phagocyte NADPH oxidase, impair the respiratory burst of all types of phagocytes and result in X-linked chronic granulomatous disease (CGD). ...
Mecanismos de resistência de camundongos BALB/c e C57BL/6 à infecção por Leishmania (Viannia) guyanensis
(Universidade Federal de Minas GeraisUFMG, 2011-02-28)
The many types of clinical manifestations of leishmaniasis, resistance or susceptibility to infection is determined by factors such as parasite species and the type of immune response of the host. In this present work, ...
Mecanismos envolvendo ativação de receptores do tipo toll9 e formação de espécies reativas na resistência do hospedeiro à infecção pelo vírus da dengue
(Universidade Federal de Minas GeraisUFMG, 2013-08-14)
Dengue is one of the most important arboviruses that affect humans and it is a serious global health problem. The disease is caused by dengue virus which is divided into four serotypes (DENV-1, DENV-2, DENV-3, DENV-4). The ...
Estudo do papel das espécies reativas de oxigênio (ROS) na resposta inflamatória induzida pelo exercício físico em camundongos
(Universidade Federal de Minas GeraisUFMG, 2014-02-03)
During an acute bout of exercise there is an activation and mobilization of immune cells into circulation. These cells may infiltrate into muscle sites inducing local inflammatory response. Skeletal muscle has many sources ...
Estudo da resposta inflamatória na artrite induzida por antígeno e o papel de mediadores endógenos na sua resolução: importância das espécies reativas de oxigênio
(Universidade Federal de Minas GeraisUFMG, 2013-02-18)
During inflammatory response there an important accumulation (arrival and permanence at inflamed site) of leukocytes, production of inflammatory mediators and, conse quently, loss of function of involved organ. Neutrophils ...
Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment
(Amer Soc Pharmacology Experimental Therapeutics, 2016-11-01)
Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The ...