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Evolution of the Metazoan Mitochondrial Replicase
(Oxford Univ Press, 2015-04-01)
The large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are ...
Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons
(Academic Press Inc., 2014)
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
(Wiley-BlackwellOxford, 2013-10-08)
BACKGROUND:
Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...
Pathological bases of oxidative stress in the development of cardiovascular diseases
(2020-01-01)
Cardiovascular disease is a term for disorders of the heart and blood vessels and its cause is multifactorial, involving behavioral, environmental, and genetic factors. All these causes can be associated with a phenomenon ...
RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid β peptide oligomers
(Frontiers Research Foundation, 2017)
© 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
Fibras musculares oxidativas e glicolíticas apresentam resposta inflamatória e alterações bioenergéticas peculiares após uma contusão musculoesquelética em ratos
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2021-02-19)
Muscle contusion represents a type of stress that disrupts cell homeostasis. Characterized by traumatic lesion, that impair the availability of oxygen (O2) in the tissue, promotes an increase in the production of reactive ...
Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice
(Wiley, 2013-09)
Abnormalities in mitochondrial content, morphology, and function were reported in several muscle wasting conditions. We specifically explored whether experimental cancer-induced cachexia may alter mitochondrial respiratory ...
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
(Humana Press, 2018-12)
Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with ...
Dopamine modifies oxygen consumption and mitochondrial membrane potential in striatal mitochondria
(Springer, 2010-04)
Dopamine is a neurotransmitter that has been related to mitochondrial dysfunction. In this study, striatal intact mitochondria and submitochondrial membranes were incubated with different dopamine concentrations, and changes ...