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Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease
(2017)
Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death. While ...
Gait score, qualidade óssea e bem-estar de frangos de corteGait score, bone quality and welfare of broiler
(Universidade Federal da Grande DouradosBrasilFaculdade de Ciências AgráriasPrograma de pós-graduação em ZootecniaUFGD, 2019)
N,N′-Dicyclohexylsulfamide and N,N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABAA receptor and anxiolytic activity in mice
(Elsevier Inc, 2012-01)
A set of sulfamides designed, synthesized and evaluated against maximal electroshock seizure (MES) and pentilenetetrazol (PTZ) tests with promising results, were tested for their affinity for the benzodiazepine binding ...
Neonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthood
(Elsevier B.V., 2011-09-12)
Depressive episodes are associated with disturbances in circadian rhythms, and constant illumination has been reported to induce depressive-like behavior in rodents. Rats kept in constant darkness express the endogenous ...
Dysbiosis prevents age-dependent phenotypes in drosophila pink1B9 a fly model for parkinson's disease
(2022)
The interaction between the enteric nervous system (ENS) and the Central nervous system (CNS), often described as the Gut-Brain Axis, consists in a bidirectional communication regulated at the endocrine, immunological and ...
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
(Pergamon-Elsevier Science Ltd, 2020-12)
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are abundantly expressed proteins in neurons of the ...
Participação do receptor metabotrópico de glutamato 5 na fisiologia de comportamentos motores e nas alterações motoras que ocorrem em camundongos modelo da doença de Huntington
(Universidade Federal de Minas GeraisUFMG, 2014-07-02)
Introduction: Huntington's disease (HD) is a neurodegenerative disorder, progressive and hereditary, that evolves inevitably to death. As we and others have demonstrated that the metabotropic glutamate receptor 5 (mGluR5) ...
Indicações da artroscopia em equinos
(Universidade Estadual Paulista (Unesp), 2009)
One of the main causes of incapacity in athletes, be they human or equines, is the occurrence of intra-articular lesions. The equines are each time more required in his athletic performance, resulting in intense stress to ...
Diagnóstico y sugerencias de adaptación ergonómica, en estancia de hogar de niños, Escuela Jean Piaget
(Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Tecnología Médica, 2020)
Este estudio se realizó en consideración de alteraciones musculoesqueléticas que se presentan a largo plazo en etapas del desarrollo infantil, definiendo como más nombradas a escoliosis y cifosis, mismas que carecen de ...
A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats
(2009-01-30)
Our previous work has shown that male Sprague–Dawley rats reared in social isolation, standard housing and environmental enrichment differ in their spontaneous open-field activity and in some neurobehavioral depressive-like ...