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Geraniol inhibits tumor cell proliferation in vitro and in vivo by posttranscriptional regulation of HMGCR
(Palacky Univ, 2012-07)
Plant isoprenoids are widely known as nontoxic natural compounds that inhibit cell proliferation with selectivity against tumor cells. Isoprenoids are also potent suppressors of the 3-hydroxy-3-methylglutaryl coenzyme A ...
Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
(Taylor & Francis, 2016-02)
Introduction: Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate to give rise to one molecule of geranyl diphosphate, which on a further reaction ...
Caracterizacao da enzima mevalonato quinase
(Universidade Federal de São Paulo (UNIFESP), 2012)
Mevalonato quinase (MVK) e uma enzima essencial na via do mevalonato. Essa via e responsavel pela biossintese de isoprenoides convertendo mevalonato em esterois como colesterol em humanos e ergosterol em tripanosomatideos. ...
Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling
(Nature Publishing Group, 2016)
Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is conserved from bacteria to mammals, and localizes ...
Sterol regulatory element-binding protein (Sre1) promotes the synthesis of carotenoids and sterols in xanthophyllomyces dendrorhous
(Frontiers Media S.A., 2019)
Xanthophyllomyces dendrorhous is a basidiomycete yeast that synthesizes carotenoids, mainly astaxanthin, which are of great commercial interest. Currently, there are many unknown aspects related to regulatory mechanisms ...
In Vivo Antimalarial Activity and Mechanisms of Action of 4-Nerolidylcatechol Derivatives
(American Society for Microbiology, 2016)
Carotenoids in bacteria : general scheme on the diversity of the biosynthetic pathways
(Universidad de los AndesMicrobiologíaFacultad de CienciasDepartamento de Ciencias Biológicas, 2020)
Carotenoids are common and diverse molecules found in several organisms including Bacteria. They are terpenoids-based molecules produced in all phototrophic bacteria as well as in some non- phototrophic ones. In this short ...
Evidence for mixed and biodegraded crude oils in the Socororo field, Eastern Venezuela Basin
(Organic Geochemistry, 2017)