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Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats
(OMICS International, 2016-01)
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for ...
Concurrent nociceptive stimulation impairs the anxiolytic effect of midazolam injected into the periaqueductal gray in mice
(Elsevier B.V., 2005-06-14)
This study investigated whether the opportunity to avoid or escape the open arms of an elevated plus-maze (EPM) affects the antinociceptive response observed when mice are subjected to open arm confinement. Furthermore, ...
Concurrent nociceptive stimulation impairs the anxiolytic effect of midazolam injected into the periaqueductal gray in mice
(Elsevier B.V., 2005-06-14)
This study investigated whether the opportunity to avoid or escape the open arms of an elevated plus-maze (EPM) affects the antinociceptive response observed when mice are subjected to open arm confinement. Furthermore, ...
Effects of electroacupuncture on stress and anxiety-related responses in rats
(Acad Brasileira de Ciências, 2017)
The aim of this work was to investigate if eletroacupuncture at PC6 would modulate the stress-induced anxiety-like behavior and the level of activation of several brain areas. Rats were distributed in groups: control; ...
Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety
(NATURE PUBLISHING GROUP, 2009)
A genomic region neighboring the alpha-synuclein gene, on rat chromosome 4, has been associated with anxiety- and alcohol-related behaviors in different rat strains. In this study, we have investigated potential molecular ...
H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
Anxiolytic-like effect of noradrenaline microinjection into the dorsal periaqueductal gray of rats
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
The brain noradrenergic system has been implicated in the expression of defensive behaviors elicited by acute stress. The dorsal periaqueductal gray area (dPAG) is a key structure involved in the behavioral and cardiovascular ...