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Mostrando ítems 91-100 de 203
Avaliação dos efeitos cardiovasculares do imatinibe em pacientes comleucemia mielóide crônica
(Universidade Federal de Minas GeraisUFMG, 2008-02-18)
Background: Imatinib mesylate (IM), a tyrosine kinase inhibitor that targets BCR-ABL, PDGFRA and c-kit, has become the first line of therapy for patients with chronic myeloid leukemia (CML) and advanced gastrointestinal ...
Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation
(Lippincott Williams and Wilkins, 2019)
Background:Adaptive immunity is crucial in cardiovascular and renal inflammation/fibrosis upon hyperactivation of mineralocorticoid receptor. We have previously demonstrated that dendritic cells can respond to mineralocorticoid ...
Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: Role in the activation of the cardiac hypertrophic genetic program
(Elsevier Science BvAmsterdamHolanda, 2005)
Acute sodium overload produces renal tubulointerstitial inflammation in normal rats
(Nature Publishing Group, 2006-10)
The aim of the present study was to determine whether acute sodium overload could trigger an inflammatory reaction in the tubulointerstitial (TI) compartment in normal rats. Four groups of Sprague-Dawley rats received ...
Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants
(Associação Brasileira de Divulgação Científica, 2011)
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific ...
cDNA microarray analysis of differentially expressed genes in penile tissue after treatment with tadalafil
(BLACKWELL PUBLISHING, 2008)
To evaluate differential gene expression in penile tissue after treatment with the phosphodiesterase 5 (PDE5) inhibitor tadalafil, as of the three clinically available PDE5 inhibitors (sildenafil, tadalafil, and vardenafil) ...
Blockage of Angiotensin II type 2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation
(DR DIETRICH STEINKOPFF VERLAG, 2010)
Although most of effects of Angiotensin II (Ang II) related to cardiac remodelling can be attributed to type 1 Ang II receptor (AT(1)R), the type 2 receptor (AT(2)R) has been shown to be involved in the development of some ...
Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection
(Academic Press Ltd-elsevier Science Ltd, 2014-06)
Trypanosoma cruzi (Tc), the etiological agent of Chagas disease, triggers multiple responses in the myocardium, a central organ of infection and pathology in the host. Parasite-driven induction of diverse regulators of ...
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
(ELSEVIER SCIENCE INC, 2010-02-15)
We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...