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Estudio del rol de los antidepresivos como moduladores de la SUMOilación y su efecto en la actividad de la co-chaperona de Hsp90 FKBP51 en el contexto neuroendócrinoStudy of the role of antidepressants as modulators of SUMOconjugation and its effect on the activity of Hsp90 co-chaperone FKBP51 in the neuroendocrine context
(2019-03-19)
La actividad del receptor de glucocorticoides (GR) se encuentra regulada por un complejo multiproteico que incluye a la co-chaperona FKBP (FK506 binding protein) 51. FKBP51 es un potente inhibidor de la función del GR. ...
The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy
(Elsevier Ireland, 2014-06)
Glucocorticoids (GCs) are steroid hormones widely used as coadjuvants in the treatment of solid tumors due to their anti-inflammatory effects. However, evidence show that they also may induce chemotherapy resistance, ...
Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats
(AMER PHYSIOLOGICAL SOC, 2010)
Ogias D, de Andrade Sa ER, Kasai A, Moisan M, Alvares EP, Gama P. Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult ...
Regulación de moléculas de la inmunidad innata por glucocorticoides : papel de la fosfoinositol 3-quinasa en la vía de señalización del receptor tipo toll 2 (TLR2)
(Universidad de Chile, 2006)
Los receptores tipo Toll (TLR) son proteínas de transmembrana que reconocen
patrones moleculares asociados a patógenos (PAMPs). El TLR2 reconoce PAMPs de
bacterias gram positivas, los cuales activan una vía de señalización ...
Modulatory role of locus coeruleus and estradiol on the stress response of female rats
(HUMANA PRESS INC, 2009)
The activity of the hypothalamic-pituitary-adrenal axis is modulated by the norepinephrinergic system and, in females, also by the ovarian hormones. We investigated the role of ovarian steroids and the locus coeruleus (LC) ...
Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
(Academic Press Inc Elsevier Science, 2018-04)
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid ...
Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions
(Cell Press, 2016-04)
The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in establishing ER-binding patterns though its ...
Morfogênese epididimária: relevância funcional de androgênios e glicocorticoides
(Universidade Federal de São Paulo (UNIFESP), 2020-07-30)
The epididymis is a single and convoluted tubule, which connects the efferent ductules to the vas deferens. It is an important organ for sperm maturation, transport, storage, and their protection before ejaculation. The ...
Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment
(Elsevier Science, 2013-03)
Throughout the lifespan, the brain has a considerable degree of plasticity and can be strongly influenced by sensory input from the outside environment. Given the importance of the environment in the regulation of the brain ...