Buscar
Mostrando ítems 91-100 de 1000
S-nitrosylation of proteins in hippocampal and cortical neurons in excitotoxicity: differential regulation of NF-kB
(2018)
Cell death by excitotoxicity is a consequence of excessive stimulation of N-methyl-Daspartate
(NMDA) receptors, causing calcium overload and synthesis of nitric oxide.
Hippocampal neurons are selectively sensitive to ...
The p.A2215D Thyroglobulin Gene Mutation Leads to Deficient Synthesis and Secretion of the Mutated Protein and Congenital Hypothyroidism with Wide Phenotype Variation
(ENDOCRINE SOC, 2009)
Context: Thyroglobulin (TG) is a large glycoprotein and functions as a matrix for thyroid hormone synthesis. TG gene mutations give rise to goitrous congenital hypothyroidism (CH) with considerable phenotype variation. ...
Sistema renina-angiotensina nas células da teca e granulosa durante a ovulação e luteinização em bovinos
(Universidade Federal de Santa MariaBrasilMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina VeterináriaCentro de Ciências Rurais, 2017-03-10)
The objective of present study was to investigate (Pro)renin receptor function in the theca and
granulosa cells during the preovulatory period and luteinization in cattle. During the initial
preovulatory period, prorenin ...
Aspectos atuais sobre aminoácidos de cadeia ramificada e exercício físico
(Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2008)
Em humanos saudáveis, nove aminoácidos são considerados essenciais, uma vez que não podem ser sintetizados endogenamente e, portanto, devem ser ingeridos por meio da dieta. Dentre os aminoácidos essenciais, se incluem os ...
Proliferative signaling initiated in ACTH receptors
(Assoc Bras Divulg Cientifica, 2000-10-01)
This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical ...
Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels
(American Association for the Study of Liver Diseases, 2013-05)
Hepatocyte mitochondrial ammonia detoxification via ureagenesis is critical for the prevention of hyperammonemia and hepatic encephalopathy. Aquaporin-8 (AQP8) channels facilitate the membrane transport of ammonia. Because ...
Activation of β 3 adrenergic receptor decreases DNA synthesis in human skin fibroblasts via cyclic GMP/nitric oxide pathway
(Karger, 2005-07)
Background: Evidences have shown that β 1 and β 2 adrenoceptors co-exist in human fibroblasts, but it is not yet clear the functional expression of β 3 adrenoceptor in these cells. The aim of this study was to investigate ...
Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells
(Ulrich Brandt, 2020-08-29)
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the
phenotype of tumoral cells and have significant implications in cancer development and progression. In this
study ...
ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion
(Elsevier Ireland LtdClareIrlanda, 2006)