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Picomolar inhibitors of HIV-1 reverse transcriptase: Design and crystallography of naphthyl phenyl ethers
(American Chemical Society, 2014-11)
Catechol diethers that incorporate a 6-cyano-1-naphthyl substituent have been explored as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Promising compounds are reported that show midpicomolar activity ...
Heterologous expression, purification and biochemical characterization of a new xylanase from Myceliophthora heterothallica F.2.1.4
(2019-06-15)
Myceliophthora heterothallica is a thermophilic fungus potentially relevant for the production of enzymes involved in the degradation of plant biomass. A xylanase encoding gene of this species was identified by means of ...
The need for enhancing the message: Screening for Zika, STORCH, and other agents and co-infections should be considered and assessed
(Wiley, 2017)
As has been addressed by Zambrano et al. in their recent paper, the Zika virus (ZIKV) isolated from the cervical cytology specimens delivered from uterus/placenta unit. Although interesting, we were concerned regarding the ...
Genomic and phylogenetic evidence of VIPER retrotransposon domestication in Trypanosomatids
(Fundação Oswaldo Cruz, 2017)
Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants
(American Chemical Society, 2015-03)
The development of novel non-nucleoside inhibitors (NNRTIs) with activity against variants of HIV reverse transcriptase (RT) is crucial for overcoming treatment failure. The NNRTIs bind in an allosteric pocket in RT ∼10 Å ...
Direct detection of infectious bursal disease virus from clinical samples by in situ reverse transcriptase-linked polymerase chain reaction
(Taylor & Francis Ltd, 2008-01-01)
The presence of the very virulent (vv) Brazilian strain of infectious bursal disease virus (IBDV) was determined in the bursa of Fabricius, thymus and liver of 2-week-old broilers from a flock with a higher than expected ...