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Brucella abortus depends on L-serine biosynthesis for intracellular proliferation
(American Society for Microbiology, 2019-11)
L-Serine is a nonessential amino acid and a key intermediate in several relevant metabolic pathways. In bacteria, the major source of L-serine is the phosphorylated pathway, which comprises three enzymes: D-3-phosphoglycerate ...
Phospholipid and phospholipase changes by jasmonic acid during stolon to tuber transition of potato
(Springer, 2008-12)
Potato tuber formation starts with the stolon swelling and is regulated by jasmonates. The cascade of events leading to tuber formation is not completely understood. The aim of this study was to evaluate phospholipid ...
Reorganization of Azospirillum brasilense cell membrane is mediated by lipid composition adjustment to maintain optimal fluidity during water deficit
(Wiley Blackwell Publishing, Inc, 2016-01)
Aims: We study the Azospirillum brasilense tolerance to water deficit and the dynamics of adaptive process at the level of the membrane. Methods and Results: Azospirillum brasilense was exposed to polyethylene glycol (PEG) ...
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy
(American Chemical Society, 2019-02)
Technological advances in mass spectrometry 14 (MS), liquid chromatography (LC) separations, nuclear 15 magnetic resonance (NMR) spectroscopy, and big data 16 analytics have made possible studying metabolism at an 17 “omics” ...
Lipid Droplets: Structure, Composition, Formation and Function. Connection with the Endoplasmic Reticulum
(Nova Science Publishers, 2019)
Fatty acids (FAs) are important compounds either used for energy production through β-oxidation, for membrane lipid synthesis, or for production of lipid mediators (oxylipins) through oxidations. FAs are also cytotoxic and ...
Comprehensive and quantitative profiling of lipid molecular species by LC-ESI-MS/MS of four native species from semiarid Patagonian Monte
(Elsevier Masson, 2019-11)
The maintenance of lipid and fatty acids unsaturated composition has been described as one of the mechanisms associated to drought tolerance, but research about the lipid profile in native plants of semiarid environment ...
Desenvolvimento de micelas poliméricas carreadoras de paclitaxel radiomarcadas com tecnécio-99m para aplicação no tratamento e diagnóstico de câncer
(Universidade Federal de Minas GeraisUFMG, 2015-08-03)
Paclitaxel (PTX) is a highly effective chemotherapeutic agent against a variety of cancers, however the use of this drug is limited due to its low aqueous solubility and high systemic toxicity. Nanocarriers based on polymeric ...
Estudo de monocamadas fosfolipidicas nanoestruturadas obtidas por LB para aplicações em biossensores
(Universidade Federal de Minas GeraisUFMG, 2007-02-16)
There has been long-standing interest in the physical chemical properties of defined mixtures of cholesterol and phospholipids in monolayer and bilayer membranes. They also provide insight into certain properties of the ...
N-terminal acetylation of a mastoparan-like peptide enhances PE/PG segregation in model membranes
(2020-10-01)
The synthetic peptides L1A and its acetylated analog (acL1A) display potent Gram-negative bactericidal activities without being hemolytic. We have gathered evidence that the N-terminal acetylation of L1A enhances the lytic ...
N-Terminal microdomain peptide from human dihydroorotate dehydrogenase: structure and model membrane interactions
(2014)
The N-terminus of the human dihydroorotate dehydrogenase (HsDHODH) has been described as important for the enzyme attachment in the inner mitochondrial membrane and possibly to regulate enzymatic activity. In this study, ...